{"created":"2023-05-15T14:51:02.383801+00:00","id":69771,"links":{},"metadata":{"_buckets":{"deposit":"efe0950a-a0d9-4801-a6ed-01e4c376526c"},"_deposit":{"created_by":1,"id":"69771","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69771"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069771","sets":["10:28"]},"author_link":["685025","685022","685017","685016","685019","685024","685018","685021","685023","685020"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-06-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The clinical radiosensitivity of normal tissue is likely to be a complex trait that is\ndependent on the cumulative effect of many minor genetic determinants. We have\nsearched for polymorphisms associated with the radiosensitivity of normal tissue in\ncancer patients who have undergone radiotherapy.\nBetween October 2001 and March 2009, 2,653 patients were recruited to our project,\nincluding 773 breast cancer patients and 855 prostate cancer patients. The candidate\ngenes for SNP typing in this project were selected by our previous comprehensive gene\nexpression analyses data using human cultured cell lines and mouse strains. We also\nadded well-known genes in the literature as responsible genes for radiosensitivity. A\ntotal of 190 genes were chosen and 1,300 SNPs have been typed using a matrix-assisted\nlaser desorption/ionization time-of-flight mass spectrometry system (MassARRAY,\nSequenom).\nThus far, we indentified multiple SNPs associated with risk of skin reaction after\nradiation therapy in breast cancer patients and another group of SNPs associated with\nrisk of urinary morbidity after radiation therapy in prostate cancer patients.\nThese data suggest that multiple genetic factors are associated with individual\nradiosensitivity in the cancer patient-groups, unlike a few Mendelian diseases with\nhypesensitivity to ionizing irradiation caused by single gene mutation such as ATM.\nIndividuals in this study contain different numbers of minor alleles affecting radiation\nsensitivity. This fact suggests that contribution of each allele to radiosensitivity may be\ntissue-specific and the strength to the sensitivity of one allele might be small and\ndissimilar each other. This would provide an understanding of the mechanisms\nunderlying the genetic variation in radiosensitivity among the population, and would\nshow the possibility of the risk prediction for the side effects prior to radiation therapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Genomic Tools & Technologies Summit","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"685016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"685017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"685018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoji, Yoshimi"}],"nameIdentifiers":[{"nameIdentifier":"685019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"685020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 智","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荘司 好美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685025","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Genetic Variation in Individual Sensitivity to Clinical Radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic Variation in Individual Sensitivity to Clinical Radiotherapy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-06-16"},"publish_date":"2009-06-16","publish_status":"0","recid":"69771","relation_version_is_last":true,"title":["Genetic Variation in Individual Sensitivity to Clinical Radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:36.535142+00:00"}