@misc{oai:repo.qst.go.jp:00069758,
 author = {Bing, Wang and Tanaka, Kaoru and Vares, Guillaume and Shang, Yi and Fujita, Kazuko and Ninomiya, Yasuharu and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru and 王 冰 and 田中 薫 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 尚 奕 and 藤田 和子 and 二宮 康晴 and 笠井 清美 and 根井 充},
 month = {May},
 note = {Numerous reports described the existence of radioinduced adaptive
response (AR), a phenomenon of priming low-dose irradiation-induced
resistance to subsequent irradiation at higher doses. AR research is of
great concern as investigations on the conditions essential for AR induction
provide important scientific basis for risk estimates and offer significant
insight into the novel biological defense mechanisms. However, all the
investigations at whole body level were performed using only low LET
X-irradiations. In a series of study, possible AR induction by accelerated
heavy ions (HI) is being attempted both in young adult female mice and in
fetal mice of C57BL/6J Jms strain, using growth delay, hematopoietic damage
and reduced survival in vivo, prenatal growth delay, malformation and death
in utero as endpoints. Investigations are to verify if priming X-irradiation
could induce any resistance against the detrimental effects from high
challenging dose of HI, if priming irradiations from HI could induce an AR
against the detrimental effects from high challenging dose of
X-irradiations, and if an AR could be induced when both priming and
challenging irradiations are from HI. Three kinds of accelerated HI from
mono beams of carbon, silicon and ion generated by HIMAC, with the LET
values of about 15, 55, and 200 keV/micrometer respectively, are being
examined. Though the essential conditions vary on particle and/or LET,
successful induction of AR is induced for the first time using HI
irradiations as either priming irradiation or challenging irradiation both
in vivo and in utero. Details will be presented and discussed., 2nd Asian Congress of Radiation Research (ACRR)},
 title = {INDUCTION OF RADIOADAPTIVE RESPONSE AT WHOLE BODY LEVEL: THE CASE OF HEAVY-ION IRRADIATIONS},
 year = {2009}
}