{"created":"2023-05-15T14:51:01.547217+00:00","id":69752,"links":{},"metadata":{"_buckets":{"deposit":"9967669d-754e-48e0-a19d-c585d280397b"},"_deposit":{"created_by":1,"id":"69752","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69752"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069752","sets":["10:28"]},"author_link":["684793","684797","684792","684798","684791","684794","684790","684795","684799","684796"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-05-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To investigate cellular responses in normal human fibroblasts induced with low dose irradiations of qualitatively different radiation types. \nMethods: Normal human fibroblasts were pre-treated with low-fluence irradiations (~1mGy/7-8h) of 137Cs gamma rays, 241Am-Be neutrons (maximum energy ; 11.5MeV, average energy ; 5.0MeV), helium (LET=2.3keV/µm), carbon (LET=13.3keV/µm) and iron ions (LET=200keV/µm) before applying irradiation with a 200kV X-ray challenging dose (1.5Gy). The 3 different ion beams were produced by the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences. \nResults: There was no difference in X-ray-induced mutation frequency, which was detected with hprt locus detected as 6-thioguanine resistant clones, between un-pretreated and gamma-ray pre-treated cells. In the case of the pre-treatment with high-LET ions, mutation frequency was around 4.0 times higher in carbon- and 1.9 times higher in helium-ion pre-treated cells than in un-pretreated cells, while no difference was observed in iron-ion pre-treated cells. On the contrary, mutation frequency in cells pre-treated with neutrons was reduced at 15% of un-pretreated cells. To identify possible mechanism(s) of the observed cellular response, cells were treated with a specific inhibitor of gap-junction mediated cell-cell communication. The results clearly showed that the observed enhancement of X-ray-induced mutation frequency in cells pre-treated with helium and carbon ions was reduced at the control level and reduction in cells pre-treated with neutrons was came back to the control level. \nConclusion: There is evidence that gap-junction mediated cell-cell communication play an important role of inducing different cellular responses by pre-treatment with different radiation types.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第二回アジア放射線連合会議（2nd Asian Congress of Radiation Research）","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"684790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruoka, Chizuru"}],"nameIdentifiers":[{"nameIdentifier":"684791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"684792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hua, Liu Cui"}],"nameIdentifiers":[{"nameIdentifier":"684793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchihori, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"684794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 尚","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉 翠華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内堀 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"684799","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Dependence in bystander cellular responses in mutation induction on normal human fibroblasts induced by the pre-treatment with different radiation types","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dependence in bystander cellular responses in mutation induction on normal human fibroblasts induced by the pre-treatment with different radiation types"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-05-22"},"publish_date":"2009-05-22","publish_status":"0","recid":"69752","relation_version_is_last":true,"title":["Dependence in bystander cellular responses in mutation induction on normal human fibroblasts induced by the pre-treatment with different radiation types"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:10:49.888921+00:00"}