@misc{oai:repo.qst.go.jp:00069630,
 author = {Yoshikawa, Kyosan and Uchino, Yoshio and Hasebe, Mitsuhiko and Ohashi, Seiya and Toubaru, Sachiko and Iwadate, Yasuo and 吉川 京燦 and 内野 福生 and 長谷部 充彦 and 大橋 靖也 and 桃原 幸子 and 岩立 康男},
 month = {Dec},
 note = {PURPOSE: Several studies have shown that the prognosis of oligodendroglial tumor is dependent on their histological grade. C-11 methionine (MET) PET imaging is one of sensitive techniques for visualizing primary brain tumors. The aim of this study was to evaluate the relationship between the uptake of MET and histopathologic grading especially based on oligodendroglial tumor versus other brain tumors.
METHOD AND MATERIALS: Cerebral uptake of MET was determined in 30 patients with histologically proven gliomas (22 male patients and 9 female patients: meanage,46.9y; range, 14-75y). Grade I, II, III and IV lesions based on WHO grading class were 3,10,9, and 8 lesions, respectively. There were 3 oligodendroglioma (grade II) and 1 anaplastic oligodendroglioma (grade III) in our cases. Ecat Exact HR+ PET scanner and Biograph DUO PET/CT were used for imaging in this study. A semiquantitative methionine uptake ratio (TNR; Tumor to normal tissue ratio) was correlated with tumor grade. 
RESULTS: There was a significant difference in TNR between grade III and IV lesions, but no significant difference between grade II and III in whole cases. In oligodendroglial tumors, 3 grade II lesions tended to show higher TNR than a grade III lesion. There was a significant difference in TNR between grade II and III lesions except oligodendroglial tumors from the cases. Oligodendroglioma might represent different metabolic demand for MET uptake from the other gliomas. 
CONCLUSION: MET PET was sensitive for histopathologic grading of gliomas except oligodedroglial tumors. We must pay much attention to primary staging of oligodendroglial tumors using MET PET. 
CLINICAL RELEVANCE/APPLICATION: Non-invasive grading technique for oligodendroglial tumor and other brain tumors using methionine PET, 94rd Scientific Assembly and Annual Meeting},
 title = {The Role of C-11 Methionine PET for Non-invasive Grading Between Oligodendroglial Tumor and Other Brain Tumors},
 year = {2008}
}