{"created":"2023-05-15T14:50:56.001465+00:00","id":69624,"links":{},"metadata":{"_buckets":{"deposit":"f6f29a99-badb-4ec1-ba75-d27c7c98f071"},"_deposit":{"created_by":1,"id":"69624","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69624"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069624","sets":["10:28"]},"author_link":["683451","683457","683463","683465","683466","683468","683469","683458","683454","683462","683452","683455","683460","683453","683456","683461","683467","683464","683459"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-12-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は以前に、水溶性ビタミンＥ誘導体が、致死線量の放射線照射からマウスを顕著に防護し、放射線防護剤として有効であることを明らかにした。これは水溶性ビタミンＥ誘導体が、放射線照射によって生体内で発生する活性酸素種やフリーラジカルを効率良く消去するためであると考えられる。本研究では、ビタミンＥのフリーラジカル消去活性を増強し、優れた放射線防護剤を開発する目的で、分子内に塩基性部位としてピリジン側鎖を有する新規ビタミンＥ誘導体を合成した。また、ラジカル消去活性を速度論的に評価し、フリーラジカル消去機構についても検討したので報告する。\n酸素非存在下、メタノール中、25℃で、得られたビタミンＥ誘導体は、DPPH(2,2-diphenyl-1-picrylhydrazyl)ラジカルを効率良く消去した。ストップトフロー法によって得られた2次の反応速度定数は、ピリジン部位をもたないビタミンＥモデルよりも約3倍大きくなった。これは分子内のピリジン部位が、ビタミンＥ骨格からDPPHラジカルへの電子移動反応で中間体として生成するビタミンＥラジカルカチオンを顕著に安定化するためであると考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本環境変異原学会第37回大会(JEMS 2008)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"683451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井, 美奈子"}],"nameIdentifiers":[{"nameIdentifier":"683452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬丸, 晴子"}],"nameIdentifiers":[{"nameIdentifier":"683453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 敬"}],"nameIdentifiers":[{"nameIdentifier":"683454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川島, 知憲"}],"nameIdentifiers":[{"nameIdentifier":"683455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福原, 潔"}],"nameIdentifiers":[{"nameIdentifier":"683456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥田, 晴宏"}],"nameIdentifiers":[{"nameIdentifier":"683457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲見, 圭子"}],"nameIdentifiers":[{"nameIdentifier":"683458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福住, 俊一"}],"nameIdentifiers":[{"nameIdentifier":"683459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田, 暢夫"}],"nameIdentifiers":[{"nameIdentifier":"683460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"683461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"683462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"683463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬丸 晴子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲見 圭子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683469","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンＥ誘導体の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンＥ誘導体の開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-08"},"publish_date":"2008-12-08","publish_status":"0","recid":"69624","relation_version_is_last":true,"title":["放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンＥ誘導体の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:12:18.789731+00:00"}