{"created":"2023-05-15T14:50:53.417317+00:00","id":69565,"links":{},"metadata":{"_buckets":{"deposit":"caff650a-803f-4c59-845e-103e27c53502"},"_deposit":{"created_by":1,"id":"69565","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69565"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069565","sets":["10:28"]},"author_link":["682808","682812","682814","682809","682810","682813","682804","682818","682806","682811","682815","682817","682805","682819","682807","682816"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】様々な遺伝子改変マウスの開発を背景に、マウスでのPETリガンド動態評価の需要が高まっている。そこで我々は11C-PIBを用い、マウス脳内でのリガンド動態定量解析を試みた。\n【方法】正常マウス（C57BL/6J, ♂9-10週齢, n=6）をイソフルラン麻酔下で11C-PIB(0.4-1.8mCi, 0.2ml)を尾静脈投与後、90分間dynamic PET撮像および大腿動脈からの頻回動脈採血を行った。血漿の放射能濃度測定と代謝物分析により入力関数を求め、PETデータと共に1-tissue compartment model（1TCM）およびグラフ法（GA）で解析し、分布容積VTを求めた。更に、2匹で4週間後にretestを行い再現性の評価をVariability(%)=100×(test-retest)/{(test+retest)/2}で行った。\n【結果と結論】VT (ml/cm3, mean±sd)は大脳皮質で0.82±0.21(1TCM), 1.1±0.3(GA)、小脳で1.1±0.2(1TCM), 1.4±0.4(GA)であった。またVariabilityは1TCMで10-27%、GAで5-26%となった。ばらつき要因の一つとして血漿量の測定誤差が考えられるが、この研究でマウスでのPET定量解析の実現性を示せた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第48回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"682804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 正希"}],"nameIdentifiers":[{"nameIdentifier":"682805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"服部, 聡子"}],"nameIdentifiers":[{"nameIdentifier":"682806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原, 美保"}],"nameIdentifiers":[{"nameIdentifier":"682807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中尾, 隆士"}],"nameIdentifiers":[{"nameIdentifier":"682808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"外山, 宏"}],"nameIdentifiers":[{"nameIdentifier":"682809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"682810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 裕一"}],"nameIdentifiers":[{"nameIdentifier":"682811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"服部 聡子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中尾 隆士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"外山 宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682819","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"入力関数を用いたマウス脳内の１１C-PIB動態の定量解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"入力関数を用いたマウス脳内の１１C-PIB動態の定量解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-11-04"},"publish_date":"2008-11-04","publish_status":"0","recid":"69565","relation_version_is_last":true,"title":["入力関数を用いたマウス脳内の１１C-PIB動態の定量解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:01.000921+00:00"}