{"created":"2023-05-15T14:50:52.671374+00:00","id":69548,"links":{},"metadata":{"_buckets":{"deposit":"20869129-249b-4f62-ac21-50ae58960f13"},"_deposit":{"created_by":1,"id":"69548","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69548"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069548","sets":["10:28"]},"author_link":["682625","682627","682614","682621","682615","682623","682626","682619","682618","682622","682620","682629","682628","682617","682624","682616","682612","682613"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim:\n     X-ray Drug Delivery System (DDS) is a combination of pinpoint X-ray and\nDDS, which can reduce side effects of radiation and chemicals.  Polymeric\nmicelle is one of the most promising DDS carriers having long circulation\nand high accumulation in solid tumor.  Cisplatin micelle is a newly\ndeveloped DDS drug which contains cisplatin (1 nm) in a polymeric micelle\n(30 nm).  The micelle collapses in the presence of chlorine ion, and the\ndrug is gradually released. To optimize the therapeutic effect, the uptake\ncharacteristics of DDS drugs should be fully understood. The aim of this\nstudy is to directly measure cellular uptake of cisplatin micelle by using\nParticle Induced X-ray Emission (PIXE).\nMethods:\n     Chinese Hamster Ovary cells were treated with cisplatin or cisplatin\nmicelle for 0.5-24 hours.  The PIXE analysis was conducted at National\nInstitute of Radiological Sciences, Chiba, Japan.  By counting the number of\ncharacteristic X-rays emitted during proton beam irradiation, the elemental\ndistribution was obtained.  The signals of Pt-L alpha (9.441 keV) were\ncorresponding to the amount of platinum contained in the cells.\nResults:\n     After 24-hours incubation, the Pt signal from the cells treated with\ncisplatin micelle was about 1/9 of that of cisplatin alone.  This result\nsuggests that cisplatin contained in a micelle is not well released in 24\nhours.  Next, the cisplatin micelle was exposed to the media, which contains\nchlorine ion, before the 24-hours incubation.  The exposure improved the\nuptake.  Amount of Pt in the cells agreed with collapsed amount of the\nmicelle.\nConclusion:\n     Uptake of cisplatin micelle was directly observed by PIXE.  The\nmicelles (30nm) did not pass through the cellular membrane, and their\ncollapsing rate (releasing rate of cisplatin) played an important role in\ncytotoxicity.  The obtained information is useful for application of DDS\ndrugs to radiation therapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"8th ASIA OCEANIA CONGRESS OF MEDICAL PHYSICS","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizuno, Kazue"}],"nameIdentifiers":[{"nameIdentifier":"682612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Azusa"}],"nameIdentifiers":[{"nameIdentifier":"682613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yusa, Noritaka"}],"nameIdentifiers":[{"nameIdentifier":"682614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"682615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamano, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"682616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"682617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iso, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"682618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"682619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"682620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imaseki, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"682621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uesaka, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"682622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱野 毅","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 剛弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯 浩之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 宝光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今関 等","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682629","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PIXE ANALYSIS OF PLATINUM-CONTAINING DDS DRUGS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PIXE ANALYSIS OF PLATINUM-CONTAINING DDS DRUGS"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-28"},"publish_date":"2008-10-28","publish_status":"0","recid":"69548","relation_version_is_last":true,"title":["PIXE ANALYSIS OF PLATINUM-CONTAINING DDS DRUGS"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:12.759086+00:00"}