@misc{oai:repo.qst.go.jp:00069521,
 author = {Saga, Tsuneo and Koizumi, Mitsuru and Yoshikawa, Kyosan and Hasebe, Mitsuhiko and Ohashi, Seiya and Tanimoto, Katsuyuki and Baba, Masayuki and Suzuki, Kazutoshi and Tsujii, Hirohiko and et.al and 佐賀 恒夫 and 小泉 満 and 吉川 京燦 and 長谷部 充彦 and 大橋 靖也 and 谷本 克之 and 馬場 雅行 and 鈴木 和年 and 辻井 博彦},
 month = {Oct},
 note = {Aim: To investigate the clinical value of FLT-PET in the evaluation of lung cancer patients treated with carbon-ion radiation therapy (CIRT). Materials & Methods: Eighteen consecutive patients (pts) with lung cancer who are going to be treated with CIRT received FLT-PET/CT before (18 pts) and 3 months after CIRT (13 pts). Fifty minutes after intravenous injection of approximately 296 MBq of FLT, PET/CT data were acquired. Maximal standardized uptake values (SUV) were measured and compared with short-term effect evaluated by the reduction of maximal tumor diameter measured by CT at 3 months post CIRT. Initial FLT uptake in the tumor was compared with the occurrence of local recurrence and/or metastasis. The study plan was approved by the Institutional Ethical Committee and informed consent was obtained from all patients before each FLT-PET examination. Results: Before CIRT, squamous cell carcinomas tended to show higher FLT uptake than adenocarcinomas did, although the difference was not statistically significant (3.70 +/- 1.88 versus 2.31 +/- 1.17, p=0.058). Three months after CIRT, both maximal diameter and maximal FLT-uptake showed significant reduction compared to those before CIRT (p=0.004 for maximal diameter and p=0.002 for SUV). There was a significant correlation between the reduction rate (RR) of FLT-uptake [(SUVpre - SUVpost)/SUVpre] and the reduction rate of maximum diameter [(Diameter-pre - Diameter-post)/Diameter-pre] (p=0.003). In 7 of 13 pts, CT showed the development of radiation pneumonitis (RP) 3 months after CIRT, and mild to weak FLT uptake was observed in the area of RP. Pts developing RP tended to show lower reduction rate of FLT-uptake than pts not developing RP (0.25 +/- 0.41 with RP versus 0.53 +/- 0.09 without RP, p=0.063). In 14 pts having more than 6-months follow-up period, 7 pts developed local recurrence and/or metastases, and pts having recurrence/metastases tended to show higher SUVpre, although not statistically significant (3.74 +/- 1.39 versus 2.81 +/- 0.82, p=0.116). Conclusion: Although the number of pts is limited and the follow up period is not long enough, the present preliminary data suggests the feasibility of FLT-PET in lung cancer patients being treated with CIRT. The presence of RP can modify the FLT uptake in the treated tumor and may cause underestimation of the CIRT effect. Although there is a possibility that higher tumor uptake of FLT before CIRT can be a predictor of recurrence/metastases, more cases are necessary to prove this., Annual Congress of the European Association of Nuclear Medicine 2008},
 title = {FLT-PET for the Evaluation of Lung Cancer Patients Treated with Carbon-Ion Radiation Therapy: Initial Results},
 year = {2008}
}