{"created":"2023-05-15T14:50:49.570480+00:00","id":69477,"links":{},"metadata":{"_buckets":{"deposit":"9eb47182-e30e-4e07-b5c6-39b2f2652486"},"_deposit":{"created_by":1,"id":"69477","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69477"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069477","sets":["10:28"]},"author_link":["681845","681848","681849","681847","681846","681844"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-12-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify network of radiation-induced apoptosis, analysis of cross-talk of the regulation was performed. Protein kinase cascades are known to regulate systems in radiation-induced apoptosis. In radiosensitive mouse thymic lymphomas, 3SBH5, Protein kinase C(PKC), a family of protein kinases, regulates the radiation-induced apoptosis.  In this cell line, participants in the PKC-related radiation-induced apoptosis regulation were explored.  In 3SBH5, after irradiation, a decreased protein was found by Western blot in immunoprecipitates with anti-PKC specific phospho-substrate antibody.  The protein was analysed by LC-MS/MS, and Mascot analysis was tried for the identification.  Some candidates were selected.  Of them, HSC70 is reported to be related to PKC regulation and cell cycle regulation. Therefore, HSC70 is a candidate of the participants.  XR223 is a radioresistant cell line, which is selected from 3SBH5.  By comparative analysis by two-dimensional electrophoresis between the cell lines, a protein, which increased in 3SBH5, but decreased in XR223 after irradiation was detected.  Furthermore, exploration of participants related to lipid mediator-related PKC cascades was performed.  We demonstrated that alteration of PKCδ regulation in 3SBH5 apparently renders the cells radiosensitive.  Lipid mediator-related PKCδ regulation might distinguish different radiosensitivity between the cell lines. Involvement of the proteins mentioned above in the radiation-induced apoptosis regulations will be discussed with other candidates.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第４５回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"681844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"681845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井, 充"}],"nameIdentifiers":[{"nameIdentifier":"681846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681849","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線感受性株を用いた放射線誘導性アポトーシス制御のクロストークの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線感受性株を用いた放射線誘導性アポトーシス制御のクロストークの解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-26"},"publish_date":"2008-09-26","publish_status":"0","recid":"69477","relation_version_is_last":true,"title":["放射線感受性株を用いた放射線誘導性アポトーシス制御のクロストークの解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:14:02.058075+00:00"}