@misc{oai:repo.qst.go.jp:00069465, author = {Kershaw, Jeffrey and Obata, Takayuki and Joonas, Autio and Shibata, Sayaka and Kuroiwa, Daigo and Kanno, Iwao and Aoki, Ichio and Kershaw Jeffrey and 小畠 隆行 and ヨーナス オーティオ and 柴田 さやか and 黒岩 大悟 and 菅野 巖 and 青木 伊知男}, month = {Sep}, note = {Diffusion-weighted fMRI has attracted some as a technique that might provide information more directly correlated with actual neural activity than BOLD fMRI.A number of interpretations have been proposed for the diffusion-weighted signal,however many questions remain unanswered.To further examine the dependence of fMRI on b-value,somatosensory forepaw stimulation was conducted on alpha-chloralose anesthetised rats at 7 T.Functional images were acquired at five b-values(b=0,200.800.1400and2000s/mm2)and two echo-times(TE=30and60ms). The mean signal changes from all rats showed a clear difference in signal amplitude between data acquired at differentTEs, although the response shape is qualitatively similar.In contrast to previous human data,the positive stimulus-correlated signal change and post-stimulus undershoot showed a slight downward (but insignificant) trend with increased b-value.Note that the undershoot persists for higher b-values. The IV contribution to the TE=60 ms data may be substantially attenuated because of the relatively short T2 of blood at7T., 第36回日本磁気共鳴医学会}, title = {Diffusion-weighted fMRI signal in rat somatosensory cortex at 7T}, year = {2008} }