{"created":"2023-05-15T14:50:41.708037+00:00","id":69325,"links":{},"metadata":{"_buckets":{"deposit":"7558a326-f2c9-428f-a208-829e76d2f36c"},"_deposit":{"created_by":1,"id":"69325","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69325"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069325","sets":["10:28"]},"author_link":["680354","680350","680355","680349","680356","680353","680348","680352","680351"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It was shown that the administration of zinc-containing yeast (zinc-yeast) to the abdominal cavity significantly increased the survival of mice irradiated with 7.5 Gy X-rays (LD50/30 assay result). In order to elucidate the molecular mechanism of this radio-protection effect, we examined TK6 (p53 wild type) and WTK1 (p53 mutant) lymphoblast cell lines exposed to 0.1mg/ml zinc-yeast. In TK6 cells, the cell growth was impaired after administration of zinc-yeast and the cells seem to accumulate at S/G2 phase in the cell cycle. On the other hand, in WTK1 cells, no effect on cell growth was observed. Furthermore, we measured the occurrence of apoptosis in X-irradiated cells (10 Gy) treated with zinc-yeast post-irradiation. In TK6 cells, a significant reduction in apoptosis was observed with the combined treatment, while there was no clear difference observed in WTK1 cells under the same treatment. These data indicate that the radio-protective effect induced by zinc-yeast might be affected by the p53 status of irradiated cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th International Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujii, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"680348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"680349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{"nameIdentifier":"680350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"680351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"680352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤井 義大","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 宝光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680356","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"radioprotective effect of zinc yeast is p53 dependent to human lymphoblastoid cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"radioprotective effect of zinc yeast is p53 dependent to human lymphoblastoid cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-21"},"publish_date":"2008-04-21","publish_status":"0","recid":"69325","relation_version_is_last":true,"title":["radioprotective effect of zinc yeast is p53 dependent to human lymphoblastoid cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:15:50.162582+00:00"}