{"created":"2023-05-15T14:50:40.627326+00:00","id":69300,"links":{},"metadata":{"_buckets":{"deposit":"09f97f0d-b8d4-41ca-8565-dc680031af13"},"_deposit":{"created_by":1,"id":"69300","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69300"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069300","sets":["10:28"]},"author_link":["680071","680073","680065","680068","680076","680072","680066","680070","680075","680067","680069","680074"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-03-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: High LET carbon ion beam cancer therapy at National Institute of Radiological Sciences (Chiba, Japan) began in 1994. Considering the expansion of heavy-ion cancer therapy, the quality and accuracy of the heavy-ion therapy must be improved and optimized. Detection of free radical reactions and geometry in a large sample irradiated by a heavy-ion beam is thus important to understand the effect of high LET irradiation in patients. Therefore, a new method to detect free radical generation, which can be translated to an imaging technique, is required. In this experiment, using an X-ray irradiation, the imaging-translational detection of H2O2 generation in an aqueous sample was tested. Method: LiPc crystal was put into a plastic microtube. The microtube was filled with mili-Q water or PBS, and sealed air-tightly without any bubble in the tube. The tube was irradiated by X-ray (Eeff = 80 keV) with dose of 256 Gy. After the irradiation, EPR spectra of LiPc in the tube were measured at L-band (1.2 GHz). The pO2 value in the tube was estimated from the linewidth of EPR spectrum of LiPc. A similar sample without LiPc was irradiated by X-ray (256 Gy), and then H2O2 concentration in the tube was measured. A water solution of TEMPOL (2 mM) was irradiated by X-ray (356 Gy), and the reduction of the EPR signal of TEMPOL was measured. Results and Discussion: By irradiating 256 Gy of X-ray, pO2 in the irradiated water was decreased by 30 mmHg, and generation of 60 mol/L H2O2 in the irradiated water was detected. When a water solution of TEMPOL (2 mM) was irradiated by 256 Gy of X-ray, EPR signal of TEMPOL in the sample was decreased. The H2O2 generated in the water during the irradiation can make the reduction of TEMPOL without hydrogen-donor, such as GSH, NADH, or NADPH. This experimental design will be translated to imaging experiment and applied to the high LET radiation such as heavy-ion beams in the future.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Oxygen Club of California 2008 World Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro"}],"nameIdentifiers":[{"nameIdentifier":"680065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"680066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nyuui, Minako"}],"nameIdentifiers":[{"nameIdentifier":"680067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"680068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manda, Sushma"}],"nameIdentifiers":[{"nameIdentifier":"680069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"680070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 厚子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乳井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｍａｎｄａ Ｓｕｓｈｍａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680076","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Free radical reaction and oxygen consumption in an aqueous solution by an X-ray irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Free radical reaction and oxygen consumption in an aqueous solution by an X-ray irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-18"},"publish_date":"2008-03-18","publish_status":"0","recid":"69300","relation_version_is_last":true,"title":["Free radical reaction and oxygen consumption in an aqueous solution by an X-ray irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:16:07.521239+00:00"}