{"created":"2023-05-15T14:50:39.659828+00:00","id":69278,"links":{},"metadata":{"_buckets":{"deposit":"fcc8bf9d-0691-4036-a15e-a368353e0799"},"_deposit":{"created_by":1,"id":"69278","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69278"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069278","sets":["10:28"]},"author_link":["679830","679832","679835","679831","679836","679834","679838","679833","679837"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-11-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: The adhesion of inflammatory cells to endothelial cells has been reported to be involved in radiation-induced fibrosis. In this process, intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-beta 1 (TGF-beta1) are suggested to play important roles. We investigated about the radiation-induced ICAM-1 expression to elucidate the relative biological effectiveness (RBE) of carbon-ion beam to X-ray with or without an inhibitor of TGF-beta1 receptor kinase (SB431542).MATERIALS AND METHODS: Cell cultures of human umbilical vein endothelial cells (HUVEC) were irradiated with single doses of 1-10Gy of the 140 KV X-ray and 0.1-5.0Gy of 220MeV carbon-ion beams (108 keV/mum). Fluorescence-activated cell sorting analysis was used to quantify ICAM-1 expression at 24 and 48 hours after irradiation with or without SB431542.RESULTS: The expression of ICAM-1 was increased after X-ray and carbon-ion beam irradiations. The expression of ICAM-1 was significantly increased with the stimulation of TGF-beta1, and decreased significantly by addition of SB431542 after carbon-ion beam irradiation. The expression of ICAM-1 increased by 6 folds with carbon-ion beam irradiation of 0.1-5Gy as compared with untreated control cells, while X-ray irradiation increased by 2.3 folds. The ICAM-1 expression was about 3 times greater in carbon-ion beam irradiation than that in X-ray irradiation.CONCLUSION: The present results suggested that radiation-induced ICAM-1 expression on HUVEC was regulated by TGF-beta1. The RBE of carbon-ion beam to X-ray was about 3 for the expression of ICAM-1.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第50回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"679830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"679831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"679832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"679833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"679834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原 浩樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"679835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"679836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 義行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"679837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"679838","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects of the heavy ion beam irradiation on the expression of ICAM-1 and TGF-beta1 on HUVEC","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of the heavy ion beam irradiation on the expression of ICAM-1 and TGF-beta1 on HUVEC"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-29"},"publish_date":"2008-01-29","publish_status":"0","recid":"69278","relation_version_is_last":true,"title":["Effects of the heavy ion beam irradiation on the expression of ICAM-1 and TGF-beta1 on HUVEC"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:16:22.261069+00:00"}