@misc{oai:repo.qst.go.jp:00069248, author = {Fujimori, Akira and Maruyama, Kouichi and Yasuda, Takako and Kubota, Yoshihisa and Takahashi, Sentaro and Ishikawa, Yuuji and 藤森 亮 and 丸山 耕一 and 久保田 善久 and 高橋 千太郎 and 石川 裕二}, month = {Dec}, note = {Fatty acid binding proteins (fabp) are a multigene family of small intracellular proteins that bind hydrophobic ligands. Recent studies have indicated that brain-type fabp plays important roles in neurogenesis or neuronal migration in vertebrates. We isolated the cDNA and the genomic fragment containing the fabp7 gene for medaka fish and examined the expression of the gene through the development of their central nervous system (CNS). The medaka fabp7 gene consists of four exons in approximately 1 kb of the genomic region. Its deduced amino acid sequence exhibits over 80% identity with those of the other higher vertebra. In situ hybridization analyses demonstrated that fabp7 positive cells first appear at st.22 in a small dorsal domain of the retina, dorsal diencephalon and rhombencephalon, then expand to the whole CNS including the retina and spinal cord. In addition, we generated two lines of transgenic medaka with 1.7 kb upstream of the fabp7 gene combined with an enhanced-green fluorescence protein gene (EGFP) as the reporter., 第30会日本分子生物学会年会}, title = {Expression of brain-type fatty acid-binding protein (Fabp7) in medaka development.}, year = {2007} }