@misc{oai:repo.qst.go.jp:00069130,
 author = {Hasebe, Mitsuhiko and Yoshikawa, Kyosan and Ishikawa, Hiroyuki and Sagou, Kenji and Kawaguchi, Koji and Seto, Kanichi and 長谷部 充彦 and 吉川 京燦 and 石川 博之 and 佐合 賢治},
 month = {Oct},
 note = {PURPOSE:C-11 methionine is a tracer for PET that can be used to assess metabolism of amino acid in tumor cells. The purpose of this study is to assess the ability of C-11 methionine PET (MET-PET) to predict prognosis of patient with adenocarcinoma in head and neck treated by carbon ion radiotherapy (CIRT).
METHOD AND MATERIALS:We studied consecutive 23 patients with proven adenocarcinoma in head and neck who had been referred to our hospital for CIRT. 15 patients were male and 8 patients were female. The average patient age was 61.9 years (range 40 to 82). Patients were followed for 5.1 to 89.8 months (mean: 31.9 months) after CIRT. We evaluated the lesion semi-quantitatively on the basis of the Tumor-to-Normal-tissue Ratio (TNR). We statistically analyzed the relationship between tumor MET uptake level at pre and post CIRT, recurrence or metastasis rate, and patient prognosis using Kaplan-Meier analysis method.
RESULTS:There were significant relationships between the level of tumor activity before CIRT and patients prognosis, recurrence and metastasis rate (p=0.029, 0.043, and 0.014) from Kaplan-Meier analysis. The level of tumor activity after CIRT also significantly related to patients prognosis, recurrence and metastasis rate (p=0.049, 0.043, and 0.014). No statistically significant relationship was observed between tumor uptake change after CIRT and survival rate.
CONCLUSIONS:MET-PET is useful to predict patients survival rate, recurrence and metastasis rate in patients with head and neck adenocarcinoma treated by CIRT., 89th AAOMS Annual Meeting, Scientific Sessions and Exhibition in conjunction with the Japanese Society of Oral and Maxillofacial Surgeons and the Korean Association of Oral and Maxillofacial Surgeons},
 title = {Usefulness of Methionine PET for predicting prognosis of patient with adenoc arcinoma in head and neck treated by carbon ion radiotherapy},
 year = {2007}
}