{"created":"2023-05-15T14:50:32.677171+00:00","id":69122,"links":{},"metadata":{"_buckets":{"deposit":"1d6f7d5e-601b-4e93-a694-d2a33922847e"},"_deposit":{"created_by":1,"id":"69122","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69122"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069122","sets":["10:28"]},"author_link":["678294","678297","678292","678288","678289","678301","678303","678283","678293","678286","678284","678290","678300","678296","678299","678287","678285","678291","678295","678302","678298"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis.\nMaterials and Methods: We examined gene expression changes after carbon-ion (C-ion) irradiation (290 MeV/m, SOBP 6 cm middle, 50 kev/&#61549;m) with a single dose of 30 Gy in four mouse tumors (NR-S1, SCCVII, NFSa, and #8520) transplanted into the hind legs of C3H/HeNrs mice, using 44K single-color oligo-microarrays at 6 hours (h), 1 day, and 3 days after irradiation. Gamma rays of 30 Gy and 50 Gy were used as a reference beam. Identification of C-ion-responsive genes was based on a false discovery rate of < 5% using the Wilcoxon test (P < 0.001) and the Benjamini-Hochberg correction. \nResults: In all tumors, the level of expression of several tens of genes, including Ccl3, Ccng1, Cd80, Cdkn1a, Cxcl2, IL7r, Lrdd, Mgmt, Mmp8, and Polk, was significantly altered 6 h and day 1 following C-ion irradiation. At day 3, several hundred genes, many of which are also classified as stress-response or cell-communication genes, including Tnfrsf5, Ikbke, Ifi202b, and Icam1, were upregulated following C-ion irradiation. The expression level of the majority of these genes was similar following &#61543;-ray treatment, although the change was not as extensive and intertumor variance was apparent. Several genes, including Ikbke, Serpina3n, and Saa3, responded differentially following C-ion irradiation than after &#61543;-ray irradiation. Pathological investigation and immunohistochemical analysis of Cdkn1a revealed cell cycle arrest with mitotic catastrophe in tumors irradiated by C-ions. \nConclusions: This study revealed significant C-ion induced up-regulation of stress-responsive and cell-communication genes common to different tumor types. These findings provide evidence for the efficacy of this modality for the treatment of local tumors.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第66回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"678283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imadome, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"678284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojiri, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"678285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamaki, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"678286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Minako"}],"nameIdentifiers":[{"nameIdentifier":"678287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"678288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritake, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"678289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagisawa, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"678290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Etsuko"}],"nameIdentifiers":[{"nameIdentifier":"678291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"678292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"678293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野尻 和典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田巻 倫明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酒井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛武 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳澤 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678303","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Prolonged expression changes of cell-cycle related genes in murine tumor models treated with carbon ion irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prolonged expression changes of cell-cycle related genes in murine tumor models treated with carbon ion irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-02"},"publish_date":"2007-10-02","publish_status":"0","recid":"69122","relation_version_is_last":true,"title":["Prolonged expression changes of cell-cycle related genes in murine tumor models treated with carbon ion irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:18:15.133065+00:00"}