{"created":"2023-05-15T14:50:32.154521+00:00","id":69110,"links":{},"metadata":{"_buckets":{"deposit":"c017956c-1067-43b7-9aab-55f592a3d98d"},"_deposit":{"created_by":1,"id":"69110","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69110"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069110","sets":["10:28"]},"author_link":["678156","678159","678153","678144","678145","678161","678148","678147","678160","678149","678143","678162","678164","678152","678142","678163","678154","678151","678157","678150","678158","678146","678155"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-09-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Using single-color oligo-microarrays, we analyzed the gene expression profiles of two murine squamous cell carcinomas: NR-S1 (radioresistant) and SCCVII (radiosensitive), after irradiation with 137-Cs gamma rays at doses of 30, 50 and 70 Gy or 290 MeV/u carbon ions at a dose of 30 Gy. Potential genes related to radiosensitivity were selected by comparing the expression values before and after irradiation (with both gamma rays and carbon ions) using a filter for at least 1.5-fold changes. Furthermore, candidate genes which had significantly different ratio values between the two tumors (P < 0.05) were detected by unpaired Student's t-tests. Subsequent analysis by quantitative reverse-transcription polymerase chain reaction (RT-PCR) confirmed our microarray data. Protein expression and function were examined by immunohistochemical studies.\nResults: Four genes, Efna1, Sprr1a, Srgap3 and Xrra1, were selected as potential genes related to radioresistance after gamma and carbon ion irradiation. RT-PCR confirmed that Efna1 was induced in radioresistant NR-S1. Efna1, a proangiogenic factor, was expressed in the cytoplasm of tumor cells and significant increases in microvascular density were observed in the radioresistant NR-S1.\nConclusions: We found that Efna1 may be a potential molecule related to radioresistance in murine tumors.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 14th European Cancer Conference, ESTRO26 meeting, European Society for therapeutic radiology and oncology","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nojiri, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"678142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"678143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"678144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imadome, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"678145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Minako"}],"nameIdentifiers":[{"nameIdentifier":"678146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"678147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"678148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"678149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togo, Shinji"}],"nameIdentifiers":[{"nameIdentifier":"678150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"678151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"678152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"678153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野尻 和典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市川 靖史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酒井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 顕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"嶋田 紘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678164","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"EFNA1, a radioresistant marker, detected in a murine tumor model by gamma and carbon ion irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFNA1, a radioresistant marker, detected in a murine tumor model by gamma and carbon ion irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-01"},"publish_date":"2007-10-01","publish_status":"0","recid":"69110","relation_version_is_last":true,"title":["EFNA1, a radioresistant marker, detected in a murine tumor model by gamma and carbon ion irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:18:23.258708+00:00"}