@misc{oai:repo.qst.go.jp:00069046,
 author = {Suga, Tomo and Iwakawa, Mayumi and Noda, Shuhei and Tsuji, Hiroshi and Oda, Eisei and Ootsuka, Yoshimi and Ishikawa, Atsuko and Tsujii, Hirohiko and Imai, Takashi and 菅 智 and 岩川 眞由美 and 野田 秀平 and 辻 比呂志 and 小田 英世 and 荘司 好美 and 石川 敦子 and 辻井 博彦 and 今井 高志},
 month = {Jul},
 note = {Purpose: To develop efficient predictive method for risk of dysuria after radiotherapy (RT). Patients and Methods: A total of 197 prostate cancer patients who underwent C-ion RT at a total dose of 64.4 +/- 2.7 GyE and evaluated for urinary morbidity (dysuria) according to the Late Effects of Normal Tissue/Subjective, Objective, Management, and Analytic scoring system (LENTSOMA). Three hundred seventy-three SNPs in 109 candidate genes were genotyped by MassARRAY system. Patients were categorized into control (grade 0) and case (grade >1) groups. First, association between the genotype at each SNP site and dysuria were assessed using the Fisher exact test (P < 0.05). Then, appropriate combination of the markers was tested by their ability to maximize area under the curve (AUC) of the receiver operating characteristic (ROC) analysis for predicting the risk of dysuria. Results: The distribution of dysuria was as follows: grade 0; 165, grade 1; 28, grade 2; 4. No grade 3 or higher toxicities were observed. The value of the AUC-ROC reached a maximum of 0.861 in the training set when the SNP markers in SART1, ID3, EPDR1, PAH, and XRCC6 were subjected to the analysis. This marker set showed that the AUC-ROC was 0.768 in the test set. The genotype of these genes was defined as 'a risk genotype'. The total number of the risk genotype in each patient was examined. Approximately 90% of patients in the case group (grade 1>) had 3 or more risk genotypes. Conclusions: Although more patients are required to validate the results, this study supports the assumptions that radiosensitivity is caused by multigenetic factors and that the number of high-risk genotypes on SNPs might predict radiosensitivity., The 13th International Congress of Radiation Research},
 title = {Possible influence of multiple SNP markers to urological morbidity induced by radiotherapy with carbon-ions among 133 prostate cancer patients},
 year = {2007}
}