@misc{oai:repo.qst.go.jp:00068933, author = {Nakanishi, Ikuo and Ohkubo, Kei and Uto, Yoshihiro and Kawashima, Tomonori and Manda, Sushma and Kanazawa, Hideko and Hori, Hitoshi and Fukuhara, Kiyoshi and Okuda, Haruhiro and Ozawa, Toshihiko and Ikota, Nobuo and Fukuzumi, Shunichi and Anzai, Kazunori and 中西 郁夫 and Manda Sushma and 小澤 俊彦 and 安西 和紀}, month = {May}, note = {Artepillin C, a major component of Brazilian propolis, is known to act as an antioxidant, which efficiently scavenges reactive oxygen species generated in the biological systems. In order to improve the radical-scavenging activity of artepillin C, we synthesized four artepillin C derivatives and compared their scavenging rate constants of cumylperoxyl radical in propionitrile at 203 K by the electron spin resonance (ESR) technique. More than two-fold higher scavenging activity of cumylperoxyl radical as compared to Artepillin C was observed with a derivative, where the isoprenyl and carboxyl groups in Artepillin C are substituted by methoxy and hydroxymethyl groups, respectively., Experimental Biology Annual Meeting 2007 (EB2007)}, title = {Enhanced Radical-Scavenging Activity of Artepillin C Derivatives}, year = {2007} }