{"created":"2023-05-15T14:50:23.292716+00:00","id":68908,"links":{},"metadata":{"_buckets":{"deposit":"136c5dbf-b9b9-4bcd-9796-ac0d6d658c11"},"_deposit":{"created_by":1,"id":"68908","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68908"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068908","sets":["10:28"]},"author_link":["676341","676335","676343","676329","676325","676326","676332","676328","676337","676338","676342","676330","676327","676336","676344","676339","676334","676340","676331","676333"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-03-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はこれまで、カテキンやレスベラトロールなどの天然抗酸化物質を化学修飾し、より強力な抗酸化活性を有する種々の新規抗酸化物質を開発してきた。本研究では、ブラジル産プロポリスの主成分であるアルテピリンＣの抗酸化活性を増強する目的で、４種類のアルテピリンＣ誘導体を合成し、クミルペルオキシルラジカル消去活性およびその反応機構について速度論的に検討した。その結果、アルテピリンＣの片方のイソプレニル基をメトキシ基で置換し、さらにカルボキシル基をヒドロキシルメチル基に還元した誘導体は、アルテピリンＣの約２倍のクミルペルオキシルラジカル消去活性を示した。密度汎関数計算により得られた水素解離エネルギーおよびイオン化エネルギーと反応速度定数の対数との相関関係から、アルテピリンＣ誘導体によるクミルペルオキシルラジカル消去反応は、電子移動ではなく、１段階の水素原子移動で進行しているいことがわかった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本薬学会第127年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中西, 郁夫"}],"nameIdentifiers":[{"nameIdentifier":"676325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇都, 義浩"}],"nameIdentifiers":[{"nameIdentifier":"676326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 敬"}],"nameIdentifiers":[{"nameIdentifier":"676327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川島, 知憲"}],"nameIdentifiers":[{"nameIdentifier":"676328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｍａｎｄａ, Ｓｕｓｈｍａ"}],"nameIdentifiers":[{"nameIdentifier":"676329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金澤, 秀子"}],"nameIdentifiers":[{"nameIdentifier":"676330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永澤, 秀子"}],"nameIdentifiers":[{"nameIdentifier":"676331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀, 均"}],"nameIdentifiers":[{"nameIdentifier":"676332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥田, 晴宏"}],"nameIdentifiers":[{"nameIdentifier":"676333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福原, 潔"}],"nameIdentifiers":[{"nameIdentifier":"676334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"676335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福住, 俊一"}],"nameIdentifiers":[{"nameIdentifier":"676336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田, 暢夫"}],"nameIdentifiers":[{"nameIdentifier":"676337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"676338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川島 知憲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｍａｎｄａ Ｓｕｓｈｍａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"676344","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"抗酸化作用の増強を目的としたアルテピリンＣ誘導体の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗酸化作用の増強を目的としたアルテピリンＣ誘導体の開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-04-02"},"publish_date":"2007-04-02","publish_status":"0","recid":"68908","relation_version_is_last":true,"title":["抗酸化作用の増強を目的としたアルテピリンＣ誘導体の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:20:42.797498+00:00"}