{"created":"2023-05-15T14:50:20.270961+00:00","id":68839,"links":{},"metadata":{"_buckets":{"deposit":"372ad391-563b-4597-877a-4f9e8a2a14ab"},"_deposit":{"created_by":1,"id":"68839","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68839"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068839","sets":["10:28"]},"author_link":["675646","675645","675642","675650","675651","675656","675647","675639","675638","675640","675653","675644","675649","675654","675643","675648","675655","675641","675652"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-01-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　X線ビームをスリットで非常に細く形成し、これを一定の間隔で取り出したマイクロプラナービームを用いて癌の治療に応用しようとする研究がある。Dilmanian FA, et al., PNAS 103, 9709-, (2006), Miura M, et al., BJR 79, 71-, (2006)\n　我々はSpring-8の白色X線回折ラインBL28B2に於いて、20?m幅のスリットを200?m間隔で10段重ねたマルチスリットを用いてマイクロプラナービームを得、全幅2mmの中に存在する10本のマイクロビームの束をさらに2mmステップで5段重ねて合計10 mm幅のビームを照射に用いた。マイクロプラナービームの腫瘍内分布を確かめるため、増殖遅延測定で用いるものと同じ腫瘍で、DNA二本鎖切断の分布をγH2AXの組織免疫染色で確認し、綺麗な帯状の照射領域が確認できた。\n　マウスは放医研生産のC3Hマウスを用い、照射8日前に下肢に1x106細胞の繊維肉腫NFSa細胞を移植し（腫瘍増殖抑制評価用）、または脱毛処理を行い（皮膚障害評価用）、照射の数日前に播磨学園都市まで空輸した。線量はピーク値で200〜1600Gy（腫瘍全体の平均値ではその1/8）の照射を腫瘍部分全体に、または同等領域の正常皮膚に行い、北里大学（青森）に空輸して腫瘍サイズの経時的変化を観察し、腫瘍体積が照射時の5倍（200→1000mm3）になるまでの日数を求め、非照射群に対する増殖遅延の日数を線量ごとに比較した。この増殖遅延時間は線量と共に増加し、800Gy照射群では6日、1600Gy照射群では18日の遅延が認められた。また皮膚反応をスコアリングし、その経時的変化を観察して正常組織障害を評価した。皮膚反応スコアも照射線量と共に増加し、２週間後にスコアが2.5を越す（湿性皮膚炎）は1200Gy以上で観察された。この結果をγ線による治療効果比（腫瘍増殖抑制：正常組織反応）として比較すると、現在のところ大きな差は見られていない。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第20回日本放射光学会年会・放射光科学合同シンポジウム","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"675638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"取越, 正己"}],"nameIdentifiers":[{"nameIdentifier":"675639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 由美子"}],"nameIdentifiers":[{"nameIdentifier":"675640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 雅雄"}],"nameIdentifiers":[{"nameIdentifier":"675641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"675642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"675643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大町, 康"}],"nameIdentifiers":[{"nameIdentifier":"675644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"675645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"675646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"675647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"取越 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輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675656","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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