{"created":"2023-05-15T14:50:19.708340+00:00","id":68826,"links":{},"metadata":{"_buckets":{"deposit":"9d5a3273-0a43-455a-9399-40d87a618be6"},"_deposit":{"created_by":1,"id":"68826","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68826"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068826","sets":["10:28"]},"author_link":["675528","675518","675525","675529","675517","675522","675527","675515","675526","675520","675524","675516","675519","675523","675521"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-10-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The peripheral benzodiazepine receptor (PBR) density was increased in the injured brain and this increase has been used as an indicator of neuronal damage and several neurodenerative disorders such as Alzheimer's disease.We have previously developed two PET ligands [11C]DAA1106 and [18F]FEDAA1106 for PBR imaging in the human brain.Using DAA1106 as a lead compound, we designed two novel iodinated ligands: N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide (1) and N-(2,5-dimethoxybenzyl)-N-(5-iodo-2-phenoxyphenyl)acetamide (2).Here,we report the chemical synthesis and in vitro binding affinities of 1 and 2 to PBR, labeling of 1 and 2 using [131I]I, and distribution of [131I]1 and [131I]2 in the rat brain.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"EANM'06 Annual Congress of The European Association of Nuclear Medicine","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"675515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"675516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"675517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Junko"}],"nameIdentifiers":[{"nameIdentifier":"675518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"675519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"675520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Halldin, Christer"}],"nameIdentifiers":[{"nameIdentifier":"675521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"675522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 稔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハルディン クリスタ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"675529","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl)acetamide: a potent iodinated radioligand for peripheral benzodiazepine receptor in brain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl)acetamide: a potent iodinated radioligand for peripheral benzodiazepine receptor in brain"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-15"},"publish_date":"2006-12-15","publish_status":"0","recid":"68826","relation_version_is_last":true,"title":["N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl)acetamide: a potent iodinated radioligand for peripheral benzodiazepine receptor in brain"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:21:40.043833+00:00"}