@misc{oai:repo.qst.go.jp:00068826,
 author = {Zhang, Ming-Rong and Maeda, Minoru and Kumata, Katsushi and Noguchi, Junko and Haradahira, Terushi and Suhara, Tetsuya and Halldin, Christer and Suzuki, Kazutoshi and 張 明栄 and 前田 稔 and 熊田 勝志 and 原田平 輝志 and 須原 哲也 and ハルディン クリスタ and 鈴木 和年},
 month = {Oct},
 note = {The peripheral benzodiazepine receptor (PBR) density was increased in the injured brain and this increase has been used as an indicator of neuronal damage and several neurodenerative disorders such as Alzheimer's disease.We have previously developed two PET ligands [11C]DAA1106 and [18F]FEDAA1106 for PBR imaging in the human brain.Using DAA1106 as a lead compound, we designed two novel iodinated ligands: N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide (1) and N-(2,5-dimethoxybenzyl)-N-(5-iodo-2-phenoxyphenyl)acetamide (2).Here,we report the chemical synthesis and in vitro binding affinities of 1 and 2 to PBR, labeling of 1 and 2 using [131I]I, and distribution of [131I]1 and [131I]2 in the rat brain., EANM'06 Annual Congress of The European Association of Nuclear Medicine},
 title = {N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl)acetamide: a potent iodinated radioligand for peripheral benzodiazepine receptor in brain},
 year = {2006}
}