{"created":"2023-05-15T14:50:15.175757+00:00","id":68723,"links":{},"metadata":{"_buckets":{"deposit":"0435d98a-daa2-4213-b7a8-5507258429e1"},"_deposit":{"created_by":1,"id":"68723","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68723"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068723","sets":["10:28"]},"author_link":["674453","674458","674459","674455","674454","674460","674457","674456"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-10-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To elucidate risk factors of genetic variants and acquired factors such as lifestyles for ossification of the posterior longitudinal ligament of the spines (OPLL) in Japan, a case-control study was carried out.  A self-administered questionnaire was obtained from 63 patients with OPLL in collaborate hospitals and age, sex and domicile-matched controls, 126 from hospital patients without OPLL and 126 from health check up in a town.  Genotypes of vitamin-D receptor gene (VDR) FokI genotype, lipoprotein lipase gene (LPL) HindIII genotype, and nucleotide pyrophosphatase gene (NPPS) IVS15-14T->C were identified by use of PCR-RFLP methods. Frequency of VDR FokI F allele was higher in OPLL (0.66) than in hospital controls (0.54) and population controls (0.56)(p<0.05), while no significant differences were found in distributions of LPL HindIII genotypes and NPPS IVS15-14T->C genotypes between cases and controls.  An univariate analysis of the data from the questionnaire survey revealed high body mass after middle age, history of diabetes, history of hypertension, lack of body pliableness or stocky body shape, and some characters in \"Type A\" tendency were significantly associated with OPLL.  A tree-based analysis to clarify confoundings among them revealed VDR FokI F allele was associated with history of diabetes, suggesting that VDR FokI F allele was the third factor of the association between OPLL and diabetes. VDR F allele was suggested to be associated with OPLL as well as diabetes.  Further case-control studies in OPLL using candidate genes of hypertension are needed to elucidate the pathogenesis in OPLL and establish an effective intervention program for OPLL.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 56th Annual Meeting of The American Society of Human Genetics","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobashi, Gen"}],"nameIdentifiers":[{"nameIdentifier":"674453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohta, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"674454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hata, Akira"}],"nameIdentifiers":[{"nameIdentifier":"674455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Washio, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"674456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Kazushi"}],"nameIdentifiers":[{"nameIdentifier":"674457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"674458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小橋 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田 薫里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674460","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Genetic and acquired factors for ossification of the posterior longitudinal ligament of the spines in Japan; a case-control study.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic and acquired factors for ossification of the posterior longitudinal ligament of the spines in Japan; a case-control study."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-10-17"},"publish_date":"2006-10-17","publish_status":"0","recid":"68723","relation_version_is_last":true,"title":["Genetic and acquired factors for ossification of the posterior longitudinal ligament of the spines in Japan; a case-control study."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:22:51.963114+00:00"}