{"created":"2023-05-15T14:50:13.360629+00:00","id":68682,"links":{},"metadata":{"_buckets":{"deposit":"8ce605de-8571-4676-95d3-1c3098a1d311"},"_deposit":{"created_by":1,"id":"68682","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68682"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068682","sets":["10:28"]},"author_link":["674057","674059","674068","674055","674066","674056","674060","674064","674067","674069","674062","674065","674061","674058","674063"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-09-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳内グルタチオン（GSH）の非侵襲的測定が統合失調症の診断・治療に貢献できる可能性が示唆されているが、1H-MRSではGSHの脳内濃度の低さ（1mM程度）や他物質の信号との重なりなどの理由から、さまざまな選択測定法が試みられている。先に我々は1.5T-MRを用いてDQF法による選択測定とLCModelによる定量解析を試みたが、ヒト脳からのGSH信号検出の再現性にやや疑問があった1)。本研究では、3T-MR上でMEGA-PRESS2),3)と通常のPRESSの比較を行いながらGSH測定最適条件（TE等）を検討した。【方法】臨床用3.0T-MR装置（Signa, GE）と送受信型QD頭部コイルを用いた。測定対象は、ファントム（NAA50mM + GSH20mM：調製時）及び健常ボランティアとした。PRESS測定条件（TE/TR = 30/5000ms、積算回数64-256）、MEGA-PRESS測定条件（選択照射位置4.56ppm、観測位置2.95ppm、TE = 68-100ms、TR = 1500ms、積算回数256-1024）。PRESSの測定データはLCModelで、MEGA-PRESSのデータはSA/GE（GEコンソール上）で解析した。【結果】ヒト脳では臨床研究に実用上有用なROI（19ml前後）で、PRESS- LCModel法によるGSH測定誤差（%SD）は15-999%（信頼性基準＜20%）と非実用的であった。一方、MEGA-PRESS法では明瞭なGSH信号ピーク（2.95ppm）が検出されたが、定量条件の検討には高S/N比を得られる27mlのROIを選択した。本研究においては、MEGA-PRESSによる GSH信号識別のための最適TEは94ms近辺であった。【結論】高磁場MR装置（３T）でのMEGA-PRESS法では、PRESS-LCModel法の場合にS/N比が不十分であった小ROIにおいても、明瞭なGSH信号ピークを得られた。これにより臨床研究に有用なROIサイズを対象に精度の高い脳内GSH定量が期待できる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第34回日本磁気共鳴医学会大会（JSMRM2006)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野中, 博意"}],"nameIdentifiers":[{"nameIdentifier":"674055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松澤, 大輔"}],"nameIdentifiers":[{"nameIdentifier":"674056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金沢, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"674057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉留, 英二"}],"nameIdentifiers":[{"nameIdentifier":"674058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小畠, 隆行"}],"nameIdentifiers":[{"nameIdentifier":"674059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 謙二"}],"nameIdentifiers":[{"nameIdentifier":"674060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松田, 豪"}],"nameIdentifiers":[{"nameIdentifier":"674061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平, 博夫"}],"nameIdentifiers":[{"nameIdentifier":"674062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野中 博意","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松澤 大輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金沢 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉留 英二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小畠 隆行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 謙二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平 博夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"674069","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"3T　1H-MRSによる脳内グルタチオン測定法の検討：　PRESS法とMEGA-PRESS法の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"3T　1H-MRSによる脳内グルタチオン測定法の検討：　PRESS法とMEGA-PRESS法の比較"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-09-19"},"publish_date":"2006-09-19","publish_status":"0","recid":"68682","relation_version_is_last":true,"title":["3T　1H-MRSによる脳内グルタチオン測定法の検討：　PRESS法とMEGA-PRESS法の比較"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:23:20.762621+00:00"}