{"created":"2023-05-15T14:50:10.099058+00:00","id":68608,"links":{},"metadata":{"_buckets":{"deposit":"35a0f3fe-163b-4bb2-bf88-9a967e85104a"},"_deposit":{"created_by":1,"id":"68608","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68608"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068608","sets":["10:28"]},"author_link":["673343","673339","673334","673329","673331","673330","673335","673337","673341","673340","673342","673344","673345","673336","673333","673332","673338"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-07-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Effects on postnatal neurophysiological development in offspring were\nstudied following exposure of pregnant Wistar rats to accelerated neon-ion\nbeams with a LET value of about 30 keV/mm at a dose range from 0.1 Gy to\n2.0Gy on the 15th day of gestation. The age at which four physiologic\nmarkers appeared and five reflexes were acquired was examined prior to\nweaning. Gain in body weight was monitored until the offspring were 3 months\nold. Male offspring were evaluated as young adults using two behavioral\ntests. The effects of X-rays at 200 kVp measured for the same biological end\npoints were studied for comparison. Our previous study on carbon-ion beams\nwith a LET value of about 13 keV/mm was also cited to elucidate a possible\nLET-related effect. For most of the endpoints at early age, significant\nalteration was even observed in offspring prenatally received 0.1 Gy of\naccelerated neon ions, while neither X rays nor carbon-ions under the same\ndose resulted in such a significant alteration compared to that from the\nsham-irradiated dams. All offspring whose mothers received 2.0 Gy died prior\nto weaning. Offspring from dams irradiated with accelerated neon ions\ngenerally showed higher incidences of prenatal death and preweaning\nmortality, markedly delayed accomplishment in their physiological markers\nand reflexes, and gain in body weight compared to those exposed to X-rays or\ncarbon ions at doses of 0.1 to 1.5 Gy. Significantly reduced ratios of main\norgan weight to body weight at postnatal ages of 30, 60 and 90 days were\nalso observed within this dose range. The results indicated that irradiation\nwith neon ions at 0.1 to 1.5 Gy on day 15 of gestation caused permanent\ngrowth alterations in offspring that were dependent on dose. The alterations\ninclude permanent growth retardation, morphological malformations in main\norgans, i.e., microcephaly, diminished reflex attainment, delayed appearance\nof physiologic markers, and changes in adult behavior. Such exposure to 0.5\nto 1.5 Gy of neon ions resulted in growth retardation and behavioral\nalterations that persisted throughout the period of study. Accelerated neon\nions generally induced more detrimental effects than carbon ions and X rays,\nindicating that prenatal radiation resulted in LET-related detrimental\neffects on postnatal development in rats.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 36th Scientific Assembly of Assembly of COSPAR","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"673329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"673330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"673331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojima, Kumie"}],"nameIdentifiers":[{"nameIdentifier":"673332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"673333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"673334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"673335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Herve, Coffigny"}],"nameIdentifiers":[{"nameIdentifier":"673336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"673337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673345","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-08-02"},"publish_date":"2006-08-02","publish_status":"0","recid":"68608","relation_version_is_last":true,"title":["Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:24:13.981095+00:00"}