{"created":"2023-05-15T14:50:07.146735+00:00","id":68544,"links":{},"metadata":{"_buckets":{"deposit":"572dc0a7-e15f-4d92-8fee-e7e8e52865fc"},"_deposit":{"created_by":1,"id":"68544","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68544"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068544","sets":["10:28"]},"author_link":["672729","672738","672739","672725","672731","672737","672734","672727","672726","672730","672736","672732","672733","672735","672728"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2001-11-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"N-[18F]Fluoroethyl-4-piperidyl acetate ([18F]FEtP4A), an analog of acetyicholine, was designed as a PET tracer for mapping braine acetylcholinesterase (AchE) activity. Thistracer was prepared by reacting 4-piperidyl acetate (P4A) with [18F]Fluoroethyl bromide ([18F]FEtBr) at 130 degree-C for 30 min. [18F]FEtP4A showed an excellent BBB permeability into brain and its initial uptake in the brain was >8% injected dose /g tissue.  The distribution pattern of radioactivity in brain was striatum>cerebral cortex>cerebellum within 10_120 min postinjection, which reflected the distribution rank pattern of AchE activity in the brain. Chemical analysis of in vivo or in vitro radioactive metabolites in mouse and rat brains indicated that. [18F]FEtP4A was specifically hydrolyzed to N-[18F]hluoroethyl-4-piperidinol([18F]FEtP4OH) by AchE.  From these results, [18F]FEtP4A may become a promising PET tracer for mapping brain AchE.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第10回日本薬学会医薬化学部会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"672725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土山, 明男"}],"nameIdentifiers":[{"nameIdentifier":"672726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平, 輝志"}],"nameIdentifiers":[{"nameIdentifier":"672727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚, 賢士"}],"nameIdentifiers":[{"nameIdentifier":"672728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勇一郎"}],"nameIdentifiers":[{"nameIdentifier":"672729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木田, 多香依"}],"nameIdentifiers":[{"nameIdentifier":"672730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野口, 順子"}],"nameIdentifiers":[{"nameIdentifier":"672731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"672732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"672733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672739","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"脳内アセチルコリンエステラーゼPETイメージング剤[18F]FEtP4Aの創製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳内アセチルコリンエステラーゼPETイメージング剤[18F]FEtP4Aの創製"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-27"},"publish_date":"2006-06-27","publish_status":"0","recid":"68544","relation_version_is_last":true,"title":["脳内アセチルコリンエステラーゼPETイメージング剤[18F]FEtP4Aの創製"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:24:57.549121+00:00"}