{"created":"2023-05-15T14:50:04.078812+00:00","id":68475,"links":{},"metadata":{"_buckets":{"deposit":"7eefef7a-a166-4aab-a1fe-f556fbdbbf24"},"_deposit":{"created_by":1,"id":"68475","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68475"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068475","sets":["10:28"]},"author_link":["672191","672197","672193","672196","672199","672192","672189","672190","672195","672194","672198"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　多くの上皮成長因子受容体(EGFR)シグナル阻害物質がガン治療における分子標的薬として開発されている。IressaはEGFRシグナル阻害剤であり化学療法に抵抗性を示す小細胞肺ガンに対して有効性が示されている。一方で我々は[11C]CH3Iを用いた[11C]Iressaの標識合成法を確立した。そこで、この[11C]Iressa とNFSa細胞を移植した担ガンマウスを用いて、腫瘍のex vivo オートラジオグラフィーを行い、[11C]Iressaの腫瘍内EGFRイメージング用PETトレーサーとしての有用性を評価した。NFSa細胞を移植して1から4週目のマウスに約1mCiの[11C]Iressaを尾静脈から投与し、30分で屠殺後、腫瘍の切片を作成してイメージングプレートに60分間コンタクトさせた。その結果、移植後1から2週間目の腫瘍でもっとも[11C]Iressaの取り込みが高く、さらに腫瘍の深層部に比べ、EGFR活性が高い思われる表層部付近に多く集積したことから、トレーサーとしての有用性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北條, 順子"}],"nameIdentifiers":[{"nameIdentifier":"672189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"672190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"672191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井, 伸彦"}],"nameIdentifiers":[{"nameIdentifier":"672192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"672193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"672194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672199","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]Iressaを用いた腫瘍のEx Vivoオートラジオグラフィー　　　　　","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]Iressaを用いた腫瘍のEx Vivoオートラジオグラフィー　　　　　"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-16"},"publish_date":"2006-06-16","publish_status":"0","recid":"68475","relation_version_is_last":true,"title":["[11C]Iressaを用いた腫瘍のEx Vivoオートラジオグラフィー　　　　　"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:25:43.754769+00:00"}