{"created":"2023-05-15T14:50:04.034935+00:00","id":68474,"links":{},"metadata":{"_buckets":{"deposit":"e283d684-2197-48d2-ad46-0a584ed33362"},"_deposit":{"created_by":1,"id":"68474","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68474"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068474","sets":["10:28"]},"author_link":["672187","672186","672180","672183","672181","672185","672188","672182","672184"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-03-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍細胞はその増殖に伴い、低酸素領域が発生することが知られている。一方、上皮成長因子受容体(EGFR)は、固形癌に多く見られその細胞膜に存在し、腫瘍細胞が増殖する際の関連分子と考えられている。我々はEGFRと低酸素領域の関係を解明することを目的とし、EGFRチロシンキナーゼ阻害剤として肺癌の治療に使用されているgefetinib(イレッサ)に注目し、C-11標識gefetinibを合成した。また、マウスの体内動態と代謝物分析を行うことにより、本化合物のPET薬剤としての可能性を検討した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本薬学会１２４年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"672180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"672181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北條, 順子"}],"nameIdentifiers":[{"nameIdentifier":"672182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十嵐, 延行"}],"nameIdentifiers":[{"nameIdentifier":"672183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 岳人"}],"nameIdentifiers":[{"nameIdentifier":"672184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"672185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672188","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]Gefetinib([11C]イレッサ)の合成とそのPET薬剤としての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]Gefetinib([11C]イレッサ)の合成とそのPET薬剤としての研究"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-16"},"publish_date":"2006-06-16","publish_status":"0","recid":"68474","relation_version_is_last":true,"title":["[11C]Gefetinib([11C]イレッサ)の合成とそのPET薬剤としての研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:25:44.457441+00:00"}