{"created":"2023-05-15T14:50:03.273608+00:00","id":68457,"links":{},"metadata":{"_buckets":{"deposit":"377c01e5-d1e7-4b4a-9cfd-229b1e98fb93"},"_deposit":{"created_by":1,"id":"68457","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68457"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068457","sets":["10:28"]},"author_link":["672038","672043","672035","672042","672034","672037","672040","672041","672039","672036"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2002-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GABA/BZ 受容体のαサブユニットは小脳では主にα1、海馬ではα1-α5が発現していると報告されている。今回BZ受容体の選択的リガンドである3H-Ro 15-4513結合の各サブユニットに対する選択性についてインビボとインビトロの系で検討を行った。マウス海馬における H-Ro 15-4513のインビトロ結合のβ-CCEによる阻害は小脳と比較してその程度が小さいものであった。さらにインビボの海馬における結合は海馬に β-CCE（1・/・）でほとんど阻害を受けないのに対し、小脳では70％異常の特異結合阻害を認めた。また、3H-Ro 15-1788の結合はインビトロ、インビボ共には海馬において用量依存的に β-CCEにより阻害された。以上の結果から H-Ro 15-4513の結合は α5サブユニットに対し高い選択性を有すること、およびその選択性がインビボの系ではより顕著になることが判明した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第42回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細井, 理恵"}],"nameIdentifiers":[{"nameIdentifier":"672034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 利光"}],"nameIdentifiers":[{"nameIdentifier":"672035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桃崎, 壮太郎"}],"nameIdentifiers":[{"nameIdentifier":"672036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 薫"}],"nameIdentifiers":[{"nameIdentifier":"672037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"672038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 修"}],"nameIdentifiers":[{"nameIdentifier":"672039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"細井 理恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 修","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"672043","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"インビボ、インビトロにおける3H-Ro 15-4513のα5サブユニット選択性について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インビボ、インビトロにおける3H-Ro 15-4513のα5サブユニット選択性について"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-15"},"publish_date":"2006-06-15","publish_status":"0","recid":"68457","relation_version_is_last":true,"title":["インビボ、インビトロにおける3H-Ro 15-4513のα5サブユニット選択性について"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:25:55.807322+00:00"}