{"created":"2023-05-15T14:49:56.492088+00:00","id":68355,"links":{},"metadata":{"_buckets":{"deposit":"538421d8-48f8-4957-bad2-282da3c37377"},"_deposit":{"created_by":1,"id":"68355","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68355"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068355","sets":["10:28"]},"author_link":["671089","671077","671078","671076","671092","671087","671085","671090","671093","671081","671091","671080","671082","671084","671086","671088","671094","671079","671083"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[目的]細胞外マトリクス糖タンパクの一種であるテネイシンＣ（ＴＮＣ）は、急性心筋梗塞後の虚血部境界の生存心筋の接着を緩め、細胞の形や配列を再編成する（組織再構築）。組織再構築を非侵襲的に診断するために、抗原認識部位の異なる２種類の抗ＴＮＣ抗体をそれぞれヨード同位体で標識し、２核種同時に静注し、抗体の臓器分布の相違を評価する。[方法]125Ｉ-4F10tt抗体(F)と131Ｉ-4C8MS抗体(C)を心筋梗塞後ラット８匹に静注し、６時間後に各臓器の125Ｉと131Ｉの％ＩＤ／ｇを求め、対応のある２群間の比較を行った。[成績]心臓の放射活性はＣにおいて有意に高値を示した。ＣはＦに比べ、血液や肝臓で低値を、腎臓で高値を示した。[結論]本研究では、抗ＴＮＣ抗体の種類が異なっても、心筋梗塞部に集積することを確認した。抗ＴＮＣ抗体のうち４Ｃ８ＭＳ抗体が画像診断に有利な可能性がある。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小高, 謙一"}],"nameIdentifiers":[{"nameIdentifier":"671076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上原, 知也"}],"nameIdentifiers":[{"nameIdentifier":"671077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"足立, 清夏"}],"nameIdentifiers":[{"nameIdentifier":"671078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田所, 裕之"}],"nameIdentifiers":[{"nameIdentifier":"671079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勝哉"}],"nameIdentifiers":[{"nameIdentifier":"671080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 恭子"}],"nameIdentifiers":[{"nameIdentifier":"671081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣江, 道昭"}],"nameIdentifiers":[{"nameIdentifier":"671082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小室, 一成"}],"nameIdentifiers":[{"nameIdentifier":"671083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野, 泰"}],"nameIdentifiers":[{"nameIdentifier":"671084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"671085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田, 修二"}],"nameIdentifiers":[{"nameIdentifier":"671086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 謙一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上原 知也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"足立 清夏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田所 裕之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勝哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野 泰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"671094","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヨード標識抗テネイシンC抗体による急性心筋梗塞後組織再構築の評価−抗体2種類の同時静注による検討−","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヨード標識抗テネイシンC抗体による急性心筋梗塞後組織再構築の評価−抗体2種類の同時静注による検討−"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-30"},"publish_date":"2006-05-30","publish_status":"0","recid":"68355","relation_version_is_last":true,"title":["ヨード標識抗テネイシンC抗体による急性心筋梗塞後組織再構築の評価−抗体2種類の同時静注による検討−"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:27:04.708217+00:00"}