{"created":"2023-05-15T14:49:45.490540+00:00","id":68126,"links":{},"metadata":{"_buckets":{"deposit":"76bcaff0-5609-43fa-88cb-62cc8583aa12"},"_deposit":{"created_by":1,"id":"68126","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68126"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068126","sets":["10:28"]},"author_link":["669016","669009","669012","669010","669011","669006","669013","669014","669004","669015","669008","669017","669002","669005","669007","669003"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的：現在使用されている放射線防護剤のほとんどは有機化合物である。無機化合物の多くは毒物のイメージがあるが、その生体作用が徐々に解明され、昨年Na3VO4（オルトバナジン酸ナトリム）の放射線誘発アポトーシスの抑制およびその機構が報告された。本研究では、照射した妊娠マウスにNa3VO4の投与を行い、胎児発生期の放射線障害軽減効果について検討した。\n材料と方法：妊娠11あるいは12日目のICRマウスを0.5〜4.0GyのX線で全身照射した後2時間目に、生理食塩水に溶解したNa3VO4を5あるいは15mg/kg腹腔内に投与し、非投与群に同量の生理食塩水を与えた。半数の動物（14〜18匹/群）は妊娠18日目に帝王切開し、胎児の状況（生存・死亡・奇形）を調べた。半数は自然出産をさせ、生仔出生、奇形および30日目の生存を調べた。\n結果：Na3VO4を非照射妊娠11日マウスに15mg /kg投与すると、胎児及び新生児に催奇形性と致死性は見られたが、5mg/kgでは毒性がなく、妊娠12日の投与群では、15mg/kgでも毒性は認められなかった。一方、高線量（3.5Gy）照射された胎児では、15mg/kgの投与により、胎児死亡と胎児奇形の軽減が見られた。さらに、中線量（1.0Gy）照射では、胎児死亡と奇形発生の軽減のみならず、新生児死亡と新生児発育遅延の軽減も認められた。現在、上記の実験で見られた放射線防護作用が、低線量（0.5Gy）照射で何処まで有効に発揮されるか解析中である。また、他の放射線防護剤との併用も実験中である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第47回日本放射線影響学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"669002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"669003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 正弘"}],"nameIdentifiers":[{"nameIdentifier":"669004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚, 奕"}],"nameIdentifiers":[{"nameIdentifier":"669005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, さつき"}],"nameIdentifiers":[{"nameIdentifier":"669006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山, ハルミ"}],"nameIdentifiers":[{"nameIdentifier":"669007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 紀夫"}],"nameIdentifiers":[{"nameIdentifier":"669008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田, 勇"}],"nameIdentifiers":[{"nameIdentifier":"669009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 さつき","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"669017","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウス器官形成後期における放射線影響の修飾：I.. Na3VO4による胎児死亡、奇形発生および新生仔死亡の軽減","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス器官形成後期における放射線影響の修飾：I.. Na3VO4による胎児死亡、奇形発生および新生仔死亡の軽減"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-07-19"},"publish_date":"2005-07-19","publish_status":"0","recid":"68126","relation_version_is_last":true,"title":["マウス器官形成後期における放射線影響の修飾：I.. Na3VO4による胎児死亡、奇形発生および新生仔死亡の軽減"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:29:47.395275+00:00"}