{"created":"2023-05-15T14:49:42.282745+00:00","id":68055,"links":{},"metadata":{"_buckets":{"deposit":"95b25b63-426a-4088-bfd6-0d7d726355dc"},"_deposit":{"created_by":1,"id":"68055","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68055"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068055","sets":["10:28"]},"author_link":["668389","668392","668397","668393","668396","668398","668400","668391","668390","668387","668403","668402","668401","668404","668394","668395","668388","668399"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2005-05-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We reported that the 4-fraction/1-week carbon ion radiotherapy, that had been conducted from April 2001 to February 2003 within a phase II clinical study, appeared to be safe and to have a promising potential as a new, radical, and minimally invasive therapeutic option for hepatocellular carcinoma (HCC) at the last ASCO annual meeting. The next clinical trial of 2-fraction/2-day carbon ion radiotherapy is going on within a phase I/II study from April 2003. Patients and Methods: Twenty-five patients with histologically proven HCC were treated with 2-fraction/2-day carbon ion radiotherapy of 32.0GyE in 6, 33.6GyE in 7, 35.2GyE in 6, and 37.0GyE in 6 in a step-wise dose-escalation study from April 2003 to August 2004. Common Toxicity Criteria, RTOG/EORTC criteria were used for evaluation of toxicity. Serial changes in Child-Pugh score were investigated after the start of therapy to evaluate its invasiveness to the liver. Anti-tumor effect was evaluated by the tumor response and directly- calculated local control rate. Results: During a median follow-up of 12.1 (3.9-19.5) months, no severe adverse effects and no treatment-related deaths occurred. In the early phase, no change in the Child-Pugh score was observed in 79% (19/24), only a 1-point increase in 17% (4/24), and 2-point increase in 4% (1/24) of the patients. In the late phase, similar observations were made in 75% (12/16), 6% (1/16), and 19% (3/16), respectively. The overall tumor response rate was 96% (24/25) at 6 months after the therapy. Local control rates were 96% (24/25) and 93% (13/14) at 6 and 12 months, respectively. Overall survival rates were 100% at 6 and 12 months, respectively. There were preliminarily no differences between the results in the current study and those in the 4-fraction carbon ion radiotherapy. Conclusion: Two-fraction carbon ion radiotherapy for HCC appears preliminarily to be safe and effective. However, further observation is needed to confirm its clinical usefulness.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"American Society of Clinical Oncology Annual Meeting 2005","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Katou, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"668387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"668388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"668389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Kazuya"}],"nameIdentifiers":[{"nameIdentifier":"668390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitabayashi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"668391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"668392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoe, Junetsu"}],"nameIdentifiers":[{"nameIdentifier":"668393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ootou, Masao"}],"nameIdentifiers":[{"nameIdentifier":"668394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"668395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 博敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口 和也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北林 宏之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大藤 正雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"668404","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Two-fraction Carbon Ion Radiotherapy for Hepatocellular Carcinoma: Preliminary Results of a Phase I/II Clinical Trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Two-fraction Carbon Ion Radiotherapy for Hepatocellular Carcinoma: Preliminary Results of a Phase I/II Clinical Trial"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-05-10"},"publish_date":"2005-05-10","publish_status":"0","recid":"68055","relation_version_is_last":true,"title":["Two-fraction Carbon Ion Radiotherapy for Hepatocellular Carcinoma: Preliminary Results of a Phase I/II Clinical Trial"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:30:36.943204+00:00"}