{"created":"2023-05-15T14:49:37.119638+00:00","id":67939,"links":{},"metadata":{"_buckets":{"deposit":"b4c1dcb6-1342-4020-8562-6640303204b7"},"_deposit":{"created_by":1,"id":"67939","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67939"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067939","sets":["10:28"]},"author_link":["667288","667282","667279","667287","667277","667281","667283","667286","667278","667284","667285","667280"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Artemisは、生まれつき放射線感受性重症複合免疫不全症（RS-SCID）として知られるヒトの遺伝子疾患の原因遺伝子であり、T細胞およびB細胞受容体遺伝子のV（D）J組換え系のNHEJ過程に関与する因子として同定されてきた。マウスでこの遺伝子を破壊すると、放射線感受性になると同時に、Tリンパ球とBリンパ球が完全に消失する。\n　ヒトの細胞におけるArtemisの役割を調べるために、我々はジーンターゲティング技術を用いてヒト大腸癌由来HCT116細胞においてArtemis遺伝子の破壊を試み、それに成功した。ヘテロ(Artemis+/-)細胞では、細胞増殖能の低下がみられた。これは、細胞増殖能についてはハプロ不全であることを示している。また、ホモ（Artemis-/-）細胞は、放射線感受性を示した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会大会　第４７回","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 雅彦"}],"nameIdentifiers":[{"nameIdentifier":"667277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五日市, ひろみ"}],"nameIdentifiers":[{"nameIdentifier":"667278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 秀雄"}],"nameIdentifiers":[{"nameIdentifier":"667279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 篤子"}],"nameIdentifiers":[{"nameIdentifier":"667280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塩見, 尚子"}],"nameIdentifiers":[{"nameIdentifier":"667281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塩見, 忠博"}],"nameIdentifiers":[{"nameIdentifier":"667282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 雅彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五日市 ひろみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 秀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 篤子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塩見 尚子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塩見 忠博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"667288","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"標的遺伝子破壊技術を用いたヒト体細胞におけるArtemis遺伝子の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"標的遺伝子破壊技術を用いたヒト体細胞におけるArtemis遺伝子の機能解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-11-29"},"publish_date":"2004-11-29","publish_status":"0","recid":"67939","relation_version_is_last":true,"title":["標的遺伝子破壊技術を用いたヒト体細胞におけるArtemis遺伝子の機能解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:31:57.713321+00:00"}