@misc{oai:repo.qst.go.jp:00067837,
 author = {Fukuda, Satoshi and Iida, Haruzo and Yan, Xueming and Xie, Yuyuan and 福田 俊 and 飯田 治三 and 厳 雪銘},
 month = {Jul},
 note = {Effects of long-term of Zn-DTPA and CBMIDA administration on reducing plutonium-induced tumors and shortening of life span in rats were examined. Two hundred eighty female rats were divided into four groups (n=40): rats of six groups were injected intraperitoneally with 0.185, 0.37 or 3.7 x105 Bq/kg of plutonium, and once 30 mmol/kg of Ca-DTPA for the first 3 days and then replace to oral administration of daily 30 mmol/kg Zn-DTPA in drinking water. The 0.185 and 0.37 x105 Bq/kg of plutonium are dose to induce frequently tumors, and 3.7 x105 Bq/kg is dose to occur early death before tumors induction. Rats of one group were injected intraperitoneally with 0.37 x105 Bq/kg of plutonium and once 30 mmol/kg of CBMIDA for the first 3 days and replace to daily 30 mmol/kg of CBMIDA in drinking water. All rats were bred until they died. 
     The lengths of life span in the all groups that chelating agents were administered were prolonged compared to those of non-treated groups. In the 0.37 x105Bq/kg of plutonium groups, life span of Zn-DTPA group was longer than that of CBMIDA group. 
In the anatomical findings, incidence of bone tumors in the 0.185 and 0.37 x105 Bq/kg of plutonium groups reduced to 0 % from 10.5 and 12.5 % of non-treated groups, but increased to 12.5 % from 0 % in the 3.7 x105 Bq/kg. Those of liver reduced to 0% from 2.5 % in the Zn-DTPA but increased to 12 % in 0.37 x105 Bq/kg, and increased to 12% from 2.5 % in the 3.7 x105 Bq/kg group. 
    We demonstrated that a long-term administration of Zn-DTPA and CBMIDA were effective to prevent the shortening of life span in the all plutonium-administered groups, and the induction of tumors in the low dose plutonium groups, but to increase tumors probably due to reduction of plutonium to the ranges that rather occur tumors and prolong of life span in the group that administered high dose of plutonium., 7th International Symposium on Chelating Agents in Biomedicine Toxicology and Therapeutics},
 title = {Effects of Long-Term Orally Administrred Zn-DTPA and CBMIDA on Reduction of Plutonium-Induced Cancers and Shorting of Life Span in Rats},
 year = {2004}
}