{"created":"2023-05-15T14:49:28.077734+00:00","id":67737,"links":{},"metadata":{"_buckets":{"deposit":"57a30ff5-3d8e-4bcd-80a7-846efe1923f8"},"_deposit":{"created_by":1,"id":"67737","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67737"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067737","sets":["10:28"]},"author_link":["665608","665614","665604","665609","665613","665611","665612","665607","665610","665605","665606","665615"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-03-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"シトクロムcのカスパーゼ活性化能を検討した。\n【結果】PNの持続的負荷によりーゼ経路活性化能の変化\nSuppression of caspase cascade activation with a unique nitration pattern of cytochrome c by peroxynitrite\n○中川秀彦、駒井信子、田草川光子、三浦ゆり、戸田年総、小澤俊彦、伊古田暢夫\n放射線医学総合研究所、東京都老人総合研究所\n\\n【目的】パーオキシナイトライト（PN）は一酸化窒素とスーパーオキシドから生ずる活性窒素種で、酸化的ストレスとして作用し細胞死を誘導する。PNは蛋白質のチロシン残基をニトロ化修飾することも知られている。PNによるシトクロムc蛋白質の修飾反応がアポトーシス機構に与える影響するかに着目して検討した。\n【方法】ラットグリオーマ細胞C6に持続的にPNを作用させ、生化学的アポトーシス指標であるカスパーゼ活性化と、蛋白質ニトロ化反応を観察した。細胞質抽出液を用いて試験管内カスパーゼ活性化反応を行ない、ニトロ化修飾されたシトクロムcのカスパーゼ活性化能を検討した。\n【結果】PNの持続的負荷により","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本薬学会第124年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川, 秀彦"}],"nameIdentifiers":[{"nameIdentifier":"665604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"駒井, 信子"}],"nameIdentifiers":[{"nameIdentifier":"665605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田草川, 光子"}],"nameIdentifiers":[{"nameIdentifier":"665606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三浦, ゆり"}],"nameIdentifiers":[{"nameIdentifier":"665607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"戸田, 年総"}],"nameIdentifiers":[{"nameIdentifier":"665608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤, 俊彦"}],"nameIdentifiers":[{"nameIdentifier":"665609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田, 暢夫"}],"nameIdentifiers":[{"nameIdentifier":"665610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川 秀彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"駒井 信子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田草川 光子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665615","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"パーオキシナイトライトによるシトクロムc特定チロシン残基のニトロ化とカスパーゼ経路活性化能の変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パーオキシナイトライトによるシトクロムc特定チロシン残基のニトロ化とカスパーゼ経路活性化能の変化"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-03-31"},"publish_date":"2004-03-31","publish_status":"0","recid":"67737","relation_version_is_last":true,"title":["パーオキシナイトライトによるシトクロムc特定チロシン残基のニトロ化とカスパーゼ経路活性化能の変化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:34:17.549053+00:00"}