{"created":"2023-05-15T14:49:17.987435+00:00","id":67518,"links":{},"metadata":{"_buckets":{"deposit":"21d3adfe-e731-427d-b23a-dac6dfc0ad79"},"_deposit":{"created_by":1,"id":"67518","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67518"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067518","sets":["10:28"]},"author_link":["663670","663667","663674","663673","663676","663668","663671","663675","663672","663669"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-10-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】１９９４年から放射線医学総合研究所で重粒子線がん治療の臨床試行が開始され、すでに１５００人を越す患者が治療を受けている。この臨床試行から、癌の種類により治療成績がＸ線とは異なることが明らかになってきた。そこでＸ線と治療効果の最も大きく異なった悪性黒色腫と、大きな差の見られなかった扁平上皮癌について、細胞の増殖抑制を指標にして放射線の種類による生物効果を調べた。\n【方法】複数のヒト腫瘍由来の悪性黒色腫細胞（ＭＭ）と扁平上皮癌細胞（ＳＣＣ）を収集した。このうちＭＭおよびＳＣＣ各１０株について、Ｘ線と放医研において臨床試行に用いられている炭素線(６ｃｍ拡大ブラックピーク；ＳＯＢＰ)の中心、平均ＬＥＴ値=５０ｋｅＶ/μｍの位置で細胞を照射し、生存率曲線を得てそれぞれの生存率曲線パラメータを解析した。\n【結果】それぞれ１０種のＭＭ及びＳＣＣの感受性の違いをα/β比で比較するとＭＭの場合、炭素線照射でＸ線に比べてα/β比は大きくなり、すなわち生存率曲線の肩が小さくなる傾向が示された。これは炭素線がＭＭに対して効果的であり、肩が小さくなることから分割照射の効果が望めることが考えられた。しかしＳＣＣの場合はＸ線でも炭素線でもα/β比に変化が見られなかった。これらの結果は臨床試行で得られた治療成績を裏付けるものと考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第46回日本放射線影響学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"青木, 瑞穂"}],"nameIdentifiers":[{"nameIdentifier":"663667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志野, 弥生"}],"nameIdentifiers":[{"nameIdentifier":"663668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"聶, 晶"}],"nameIdentifiers":[{"nameIdentifier":"663669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"663670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"663671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志野 弥生","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"聶 晶","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663676","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"がん細胞の放射線応答特性の違いと重粒子線治療成績-II","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん細胞の放射線応答特性の違いと重粒子線治療成績-II"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-09"},"publish_date":"2003-10-09","publish_status":"0","recid":"67518","relation_version_is_last":true,"title":["がん細胞の放射線応答特性の違いと重粒子線治療成績-II"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:36:48.678174+00:00"}