{"created":"2023-05-15T14:49:17.564865+00:00","id":67509,"links":{},"metadata":{"_buckets":{"deposit":"e4fabde1-1513-4ab3-bc67-c710632c5d98"},"_deposit":{"created_by":1,"id":"67509","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67509"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067509","sets":["10:28"]},"author_link":["663565","663569","663570","663566","663567","663574","663573","663571","663572","663568"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-10-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"B10.p53+/-マウスに６Gy照射後5,6,7,9週目に30Gy全身照射、24時間後の残存CD4,CD8 両陽性胸腺細胞を回収しp53遺伝子型をPCR法により解析した。両陽性胸腺細胞が相対的に多数残存したサンプルについては、6Gy照射後５週目においても105個のオーダーでp53ホモ欠失細胞の存在が確認された。また、p53ホモ欠失と確認されたCD4,CD8 両陽性胸腺細胞の多くがTL(胸腺リンパ腫)抗原陽性であった。染色、回収、遺伝子解析には105個程度の細胞の存在が必要であり、遺伝子型は解析できなかったが、6Gy照射後4週目においても104個のオーダーでTL陽性,放射線抵抗性CD4,CD8 両陽性胸腺細胞が存在するサンプルが存在した。\nしたがって、6Gy照射後５週目において105個のオーダーでp53ホモ欠失CD4,CD8両陽性胸腺細胞が存在するマウス個体が存在することから、照射後比較的早期(２,３週目)に増殖性のp53-/-両陽性胸腺細胞が出現できる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第46回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"相澤, 志郎"}],"nameIdentifiers":[{"nameIdentifier":"663565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"663566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 雅彦"}],"nameIdentifiers":[{"nameIdentifier":"663567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, さつき"}],"nameIdentifiers":[{"nameIdentifier":"663568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 和子"}],"nameIdentifiers":[{"nameIdentifier":"663569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤 志郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 雅彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 さつき","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663574","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ｐ５３ヘテロ欠失マウスからの放射線誘発胸腺リンパ腫発生過程におけるｐ５３ホモ欠失胸腺細胞の出現の解析：続報","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ｐ５３ヘテロ欠失マウスからの放射線誘発胸腺リンパ腫発生過程におけるｐ５３ホモ欠失胸腺細胞の出現の解析：続報"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-09"},"publish_date":"2003-10-09","publish_status":"0","recid":"67509","relation_version_is_last":true,"title":["ｐ５３ヘテロ欠失マウスからの放射線誘発胸腺リンパ腫発生過程におけるｐ５３ホモ欠失胸腺細胞の出現の解析：続報"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:36:54.901821+00:00"}