@misc{oai:repo.qst.go.jp:00067416, author = {孫, 学智 and 高橋, 千太郎 and 久保田, 善久 and 野島, 久美恵 and 孫 学智 and 高橋 千太郎 and 久保田 善久 and 野島 久美恵}, month = {Jul}, note = {In order to clarify the radiation sensitivity of a specific brain region individually without a mutual interaction with other brain regions, we have developed an experimental system for irradiating a small and restricted region of the rat brain, using the feature of accelerated heavy-ion beams.Male Sprague-Dawley rats, aged 10-14 weeks and weighing 225-320 g, were used. The left cerebral hemispheres of the rat brains were irradiated at doses of 30, 50 or 100 Gy with charged carbon particles (290 MeV/nucleon; 5 mm spread-out Bragg peak), and effects of local accelerated heavy-ion irradiation on the rat brain were studied after irradiation. Gross anatomy of the brain was examined using a clinical magnetic resonance imaging system, behavioral and histological changes were observed at different ages of the rat., 第43回日本先天異常学会学術集会}, title = {Effects of local accelerated heavy-ion irradiation on the rat brain}, year = {2003} }