@misc{oai:repo.qst.go.jp:00067390,
 author = {Fukuda, Satoshi and Iida, Haruzo and Nonaka, Kiichi and 福田 俊 and 飯田 治三 and 野中 希一},
 month = {Jun},
 note = {Bone mineral density (BMD) is widely used as a parameter to estimate bone fracture risk. The BMD of long bones (tibia, femur and humerus) that the body weight burden is different, larger on the fore limbs than the hind limbs, were measured to examine whether BMD is reliable as a parameter to estimate the risk of bone fracture. The long bones labeled with tetracycline were obtained from female beagle dogs aged from 2 to 16 years. The cortical BMD and related parameters such as cortical area, thickness and strength strain index (SSI) in the mid-diaphysis of long bones were measured by pQCT. Thereafter, the undecalcified bone section was obtained to observe the bone activity by differentiating tetracycline-labeled, and eroded osteons in the anterior and posterior regions. The cortical BMD of mid-diaphysis was not different among three bones and decreased after 7-8 years. The cortical area of humerus was larger than those of tibia and femur, and the cortical thickness of humerus as well as tibia was wider than that of femur, and both values decreased after 7-8 years. The SSI of humerus was higher than femur and tibia after 7-8 years. In the mid-diaphysis of tibia, the tetracycline-labeled osteons were observed in the anterior region more than in the posterior region and decreased with age. The osteons with erosion was frequently in the posterior regions with increasing age. The results indicate that the bone strength (SSI) depends on the shapes such as cortical area and thickness rather than the BMD and the alteration of osteonal activity and morphology., 1st Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research},
 title = {Cortical Bone Mineral Density and Osteonal Activity in Mid-diaphysis of Long Bones in Female Beagle Dogs},
 year = {2003}
}