@misc{oai:repo.qst.go.jp:00067189,
 author = {Ishihara, Hiroshi and Tanaka, Izumi and Nojima, Kumie and Furuse, Masako and Shimada, Yoshiya and Nishimura, Mayumi and Yoshinaga, Yuko and 石原 弘 and 田中 泉 and 野島 久美恵 and 古瀬 雅子 and 島田 義也 and 西村 まゆみ},
 month = {Mar},
 note = {Mouse genome contains 1000 copies of intracisternal A-particle (IAP) DNA element that is closely related with endogeneous retrovirus. The IAP RNA is reversely transcribed and the cDNA is inserted into genomic DNA by the retrotransposition mechanism. Since functions of the gene at or nearby the novel insertion site of IAP cDNA are modified, the IAP element is presumable as endogenous mutagen. We found that genomic DNA rearrangement by the IAP-mediated retrotransposition is augmented in the myeloid leukemia cells in C3H/He inbred mouse.
Radiation-induced tumors are originated from cells in regenerated tissues after serious damages by ionizing radiation. In the regenerated myeloid cells following irradiation of sublethal doses at 3Gys of x-ray, the transcription level of a limited type among structural variants of the IAP elements in the genome were increased. Rearrangements of genomic DNA by unique insertions of the limited type of IAP cDNA are found in all the cell lines of acute myeloid leukemia induced by the radiation. This type of retrotransposition was observed in limited cell lines of radiation-induced thymic lymphoma and was hardly detected in the cells of non-hematopoietic tumor including skin carcinoma and hepatic tumors. Similar activation was not observed in the most types of IAP element. These findings indicate that an activation of the limited type of IAP element by radiation damage contributes to the genomic instability in the myeloid cells in C3H., The 2nd International Workshop on Space Radiation Research},
 title = {Frequent Rearrangement of Genomic DNA by an Endogeneous Retrovirus in Radiation-induced Myeloid Leukemia Cells of C3H/He Inbred Mice},
 year = {2002}
}