{"created":"2023-05-15T14:48:55.765023+00:00","id":67025,"links":{},"metadata":{"_buckets":{"deposit":"a5e95d53-f0c2-42c0-bb3e-6f04e30fc68a"},"_deposit":{"created_by":1,"id":"67025","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67025"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067025","sets":["10:29"]},"author_link":["658836","658825","658833","658819","658834","658827","658818","658837","658826","658822","658823","658816","658828","658832","658817","658824","658821","658820","658829","658831","658835","658830"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景・目的】神経ペプチドY（NPY）は中枢神経系に広く存在し、食欲、エネルギー消費、記憶、血圧調節に関与している。NPYの機能は受容体（Y1, Y2, Y4, Y5）を介して行われ、Y1受容体は脳及び末梢で広く発現している。我々は、Y1受容体選択的リガンドであるBMS193885（BMS）を11C標識した[11C]BMS及び[11C]脱メチルBMS ([11C]DMBMS)を合成し、インビボ評価した。【方法】[11C]BMSはメチル化反応により、[11C]DMBMSはホスゲンを標識中間体とする反応により合成し、マウスによる分布実験及び血漿代謝物実験を行った。【結果】両トレーサーはともにインビボ実験に適した収量、比放射能、放射化学的純度で合成できた。両トレーサーとも放射能集積は、脳では低く、小腸、腎臓、肝臓では高く、BMS前処理によりY1受容体が多く存在する腎臓、肺、脾臓で阻害された。[11C]BMSもしくは[11C]DMBMS投与後30分でのマウス血漿中での未変化体は、12％及び20％であり、さらにBMSからDMBMSへ代謝されることを示した。【結論】[11C]BMS及び[11C]DMBMSを用いることでBMSの薬物動態及び代謝の解明に有用であると示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第５８回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"658816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"658817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"658818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"658819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"658820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"658821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"658822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"658823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"658824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"658825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"658826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 若菜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 崇之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658837","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"神経ペプチドY-Y1受容体アンタゴニストBMS193885及び脱メチル体の11C標識合成及びインビボ評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経ペプチドY-Y1受容体アンタゴニストBMS193885及び脱メチル体の11C標識合成及びインビボ評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-10"},"publish_date":"2018-12-10","publish_status":"0","recid":"67025","relation_version_is_last":true,"title":["神経ペプチドY-Y1受容体アンタゴニストBMS193885及び脱メチル体の11C標識合成及びインビボ評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:42:20.600375+00:00"}