{"created":"2023-05-15T14:48:54.964900+00:00","id":67007,"links":{},"metadata":{"_buckets":{"deposit":"14887dd4-6155-4b81-adb0-98b4179bc5e0"},"_deposit":{"created_by":1,"id":"67007","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67007"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067007","sets":["10:29"]},"author_link":["658691","658684","658685","658683","658686","658687","658690","658689","658688","658692"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は自動合成装置を用い、(rac)/(R)/(S)-[18F]エピフルオロヒドリン([18F]EFH)を標識中間体とし、フェノール前駆体と反応させることにより、(3-[18F]フルオロ-2-ヒドロキシ)プロピル基を有するPETプローブを数種合成した。本研究では、[18F]EFHと2-ニトロイミダゾールとの反応による[18F]FMISOの合成を行った。また、従来の[18F]FMISO合成法と比較し、原料の量、反応温度およびHPLC分離などの反応と分離条件の最適化を行った。その結果、2-ニトロイミダゾール(1-2mg)を用いた反応では、収率19-36%で[18F]FMISOが得られた。また、従来法での前駆体の大量使用(>5mg)に比べ、蒸留により精製された[18F]EFHを用いたため、HPLCによる分離効率が著しく向上し、最終製剤中の原料混入は極端に少なかった。さらに(R)/(S)-[18F]EFHを用いることで(R)/(S)-[18F]FMISOをそれぞれ98%eeで得ることができた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第58回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"658683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"658684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"658685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"658686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"658687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 崇之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658692","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[18F]エピフルオロヒドリンによる[18F]FMISOの標識合成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[18F]エピフルオロヒドリンによる[18F]FMISOの標識合成"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-27"},"publish_date":"2018-11-27","publish_status":"0","recid":"67007","relation_version_is_last":true,"title":["[18F]エピフルオロヒドリンによる[18F]FMISOの標識合成"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:42:33.713184+00:00"}