{"created":"2023-05-15T14:48:53.840162+00:00","id":66981,"links":{},"metadata":{"_buckets":{"deposit":"da16fb64-2320-46a3-9a3b-a32d561f5262"},"_deposit":{"created_by":1,"id":"66981","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66981"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066981","sets":["10:29"]},"author_link":["658383","658392","658390","658389","658385","658382","658391","658377","658386","658380","658376","658379","658384","658381","658378","658387","658388"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction Monoacylglycerol lipase (MAGL) is considered as a novel therapeutic target of CNS disorders. [18F]T-401 has been developed as a reversible and selective PET imaging agent. The aim of this study was to test the capability of [18F]T-401 for imaging MAGL in rat and monkey brains. \nMethods In vitro ARG was performed to evaluate [18F]T-401 binding to MAGL. [18F]T-401-PET imaging was conducted with and without pre-treatments with unlabeled T-401 and several doses of an MAGL inhibitor, JW642.\nResults ARG and PET demonstrated specific [18F]T-401 binding corresponding to MAGL distribution. [18F]T-401 kinetics was reversible and enabled estimation of total distribution volume (VT) in monkey brains. Pretreatment of monkeys with JW642 reduced VT values in a dose-dependent manner. Conclusion The current observations support the utility of [18F]T-401 for quantitative PET evaluation of MAGL.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第58回日本核医学会学術総会に参加し武田薬品との共同研究成果を発表","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"658376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"服部, 靖志"}],"nameIdentifiers":[{"nameIdentifier":"658377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 純"}],"nameIdentifiers":[{"nameIdentifier":"658378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永井, 裕司"}],"nameIdentifiers":[{"nameIdentifier":"658379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内田, 翔子"}],"nameIdentifiers":[{"nameIdentifier":"658380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 正希"}],"nameIdentifiers":[{"nameIdentifier":"658381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"658382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池竜樹"}],"nameIdentifiers":[{"nameIdentifier":"658383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"658384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"服部 靖志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永井 裕司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内田 翔子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"658392","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"新規モノアシルグリセロールリパーゼPETリガンド[18F]T-401の前臨床評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規モノアシルグリセロールリパーゼPETリガンド[18F]T-401の前臨床評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-19"},"publish_date":"2018-11-19","publish_status":"0","recid":"66981","relation_version_is_last":true,"title":["新規モノアシルグリセロールリパーゼPETリガンド[18F]T-401の前臨床評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:42:48.906129+00:00"}