{"created":"2023-05-15T14:48:50.809197+00:00","id":66910,"links":{},"metadata":{"_buckets":{"deposit":"0586b0c2-53e7-4a7f-b95a-152f1e5f83e9"},"_deposit":{"created_by":1,"id":"66910","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66910"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066910","sets":["10:29"]},"author_link":["657811","657813","657809","657810","657806","657804","657803","657812","657805","657814","657808","657807"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-09-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】211At標識メタアスタトベンジルグアニジン（MABG）はノルエピネフリントランスポーター（NET）を介して褐色細胞腫内に取り込まれる。ヒストンジアセチラーゼ阻害薬であるVorinostat（SAHA）はがん治療に使用される一方、NET発現を高めることが知られており、SAHA併用によりMABGの治療効果を効果的に高めることができる可能性がある。そこで、MABG治療におけるSAHA併用の有効性をin vitroで検討した。\n【方法】ラット褐色細胞腫細胞PC12及びマウス線維芽細胞NIH/3T3において、SAHA処置後のNET発現量及びMABG取込みを検討した。更にMABGとSAHA併用時の細胞障害活性を検討した。\n【結果】PC12におけるNET発現はSAHA (3 μM) 処置後48時間で約2.8倍に増加した。また、SAHA処置後のMABG取込みに有意な増加が認められた。さらに、MABGとSAHAの併用により細胞増殖抑制効果も有意に高まった。一方、NIH/3T3ではSAHA処置後のNET発現及びMABG取込みの変化は殆ど認められなかった。\n【結論】SAHAは自身の細胞障害効果と共に、褐色細胞腫細胞におけるMABG取込み増加させることで、MABGを用いた褐色細胞腫治療効果を高める可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第2回日本核医学会分科会放射薬品科学研究会/第18回放射性医薬品・画像診断薬研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"657803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 茂樹"}],"nameIdentifiers":[{"nameIdentifier":"657804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 一郎"}],"nameIdentifiers":[{"nameIdentifier":"657805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂下, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"657806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"657807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"657808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島 康宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 茂樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂下 哲哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657814","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"MABGを用いた悪性褐色細胞腫治療におけるVorinostatの有効性の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MABGを用いた悪性褐色細胞腫治療におけるVorinostatの有効性の探索"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-14"},"publish_date":"2018-09-14","publish_status":"0","recid":"66910","relation_version_is_last":true,"title":["MABGを用いた悪性褐色細胞腫治療におけるVorinostatの有効性の探索"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:43:35.412084+00:00"}