{"created":"2023-05-15T14:48:48.903331+00:00","id":66867,"links":{},"metadata":{"_buckets":{"deposit":"d1c61a52-c90f-4598-b232-77c3161a701f"},"_deposit":{"created_by":1,"id":"66867","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66867"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066867","sets":["10:29"]},"author_link":["657448","657445","657443","657440","657442","657446","657447","657441","657449","657444"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-07-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】カドヘリン17（CDH17）は胃がん等の消化器腺がんで高発現しており、リンパ節転移でも発現が認められることから、イメージング標的として有用である。本研究では、胃がん移植腫瘍への高集積が認められた抗CDH17 IgGを改変し、小分子化抗体ミニボディを開発した。体内分布実験およびPETイメージングを用いて、体内動態を評価した。\n【方法】体内分布実験として、64Cu標識抗CDH17ミニボディを胃がんモデルマウスの尾静脈より投与した（10μCi/10μg）。投与3,6,24時間後に臓器を摘出し、集積率（%ID/g）を評価した。PETイメージング実験では、同モデルマウスに同ミニボディ100μCi/10μgを投与した。投与後3,6,24時間時点でInveonによるPET撮像を実施した。\n【結果】64Cu標識抗CDH17ミニボディは投与後24時間時点で腫瘍集積11.2%ID/g、腫瘍血液比11.0の結果を示した。PETイメージングにより，移植腫瘍が描出され、迅速な血中クリアランスが確認された。\n【結論】本プローブでのCDH17陽性胃がんの非侵襲的画像化の可能性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第14回小動物インビボイメージング研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 健太郎"}],"nameIdentifiers":[{"nameIdentifier":"657440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"657441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"657442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"657443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"657444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 健太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657449","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"胃がんに対する64Cu標識抗CDH17ミニボディのPETイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃がんに対する64Cu標識抗CDH17ミニボディのPETイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-08-01"},"publish_date":"2018-08-01","publish_status":"0","recid":"66867","relation_version_is_last":true,"title":["胃がんに対する64Cu標識抗CDH17ミニボディのPETイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:44:01.669570+00:00"}