@misc{oai:repo.qst.go.jp:00066778,
 author = {小藤, 昌志 and 高木, 亮 and 林, 和彦 and 伊川, 裕明 and 小藤 昌志 and 高木 亮 and 林 和彦 and 伊川 裕明},
 month = {Apr},
 note = {Abstract
Purpose: The purpose of this study is to determine the risk factors for developing radiation-induced radiation-induced oroantral or oronasal fistula after carbon-ion radiotherapy.
Materials and Methods: Sixty-two patients with oral or sinonasal tumors who were followed up more than 5 years after carbon-ion radiotherapy were included in this study. Carbon-ion radiotherapy was delivered to 57.6 Gy or 64.0 Gy (RBE) /16 fractions. The clinical factors for the radiation-induced oroantral or oronasal fistula were analyzed using multivariate logistic regression model. 
Results: The median follow up period was 88.8 months. Twenty-three patients (37%) developed the radiation-induced oroantral or oronasal fistula. Multivariate logistic regression analysis showed that the number of the teeth in the volume receiving more than 50 Gy (RBE) was a significant risk factor (odds ratio 2.782). Of the 62 patients, 46 without maxillary invasion were re-analyzed to clarify the effect of the dose-volume factors of the maxilla. The data of maxillary V10-60 and D1-5 were added to the multivariate logistic regression model. Consequently, the number of the teeth in the volume receiving more than 50 Gy (RBE) was a significant risk factor (odds ratio 2.466).
Conclusions: The presence of the teeth was the strongest predictive factor for developing oroantral or oronasal fistula., H29年度HIMAC共同利用研究成果発表会},
 title = {頭頸部腫瘍に対する炭素イオン線治療後の口腔‐鼻副鼻腔瘻の危険因子に関する研究},
 year = {2018}
}