{"created":"2023-05-15T14:48:42.592904+00:00","id":66728,"links":{},"metadata":{"_buckets":{"deposit":"db6dcc08-8eea-405a-9662-14a34a9a5e59"},"_deposit":{"created_by":1,"id":"66728","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66728"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066728","sets":["10:29"]},"author_link":["656181","656189","656187","656185","656182","656179","656188","656190","656175","656180","656177","656176","656184","656183","656178","656186"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-10-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】悪性褐色細胞腫への131I-MIBGの治療効果は限定的であり、新規治療法開発が望まれる。I-131をα線放出核種At-211に置換した211At-MABGは、悪性褐色細胞腫の治療薬剤と予想される。本研究の目的は、褐色細胞腫マウスモデルに211At-MABGを投与し、抗腫瘍効果の評価と病理学的解析を行う事。\n【方法】PC-12移植マウスに15Ci, 30Ciの211At-MABGを尾静脈より単回投与。\n【結果】211At-MABG投与群は腫瘍増殖が対照に比して抑制された(15 µCi: 9.6±5.5% vs control: 509.2±169.1%, P < 0.01; 30 µCi: 3.3±3.4% vs control, P < 0.01)。211At-MABG投与後の腫瘍の経時的な病理解析では、1日後にリンパ球の浸潤とネクローシスの誘導、7日後には線維化が観察された。\n【結論】211At-MABGは早期に細胞死を高度に誘導し、悪性褐色細胞腫の治療に有用と示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉永, 恵一郎"}],"nameIdentifiers":[{"nameIdentifier":"656175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"656176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"656177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"656178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津, 弘太郎"}],"nameIdentifiers":[{"nameIdentifier":"656179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"656180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"656181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"656182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉永 恵一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島 康宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"656190","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"褐色細胞腫マウスモデルを用いた211At-MABGの抗腫瘍効果の病理解析による検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"褐色細胞腫マウスモデルを用いた211At-MABGの抗腫瘍効果の病理解析による検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-27"},"publish_date":"2018-03-27","publish_status":"0","recid":"66728","relation_version_is_last":true,"title":["褐色細胞腫マウスモデルを用いた211At-MABGの抗腫瘍効果の病理解析による検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:45:38.762943+00:00"}