{"created":"2023-05-15T14:48:41.068514+00:00","id":66695,"links":{},"metadata":{"_buckets":{"deposit":"68f00d1d-690f-4510-b651-2618e0c0eb6f"},"_deposit":{"created_by":1,"id":"66695","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66695"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066695","sets":["10:29"]},"author_link":["655841","655843","655838","655842","655839","655840","655837"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-08-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、様々なラジオアイソトープ（以下RI）で標識した薬剤を用いてがんを選択的に殺傷する標的アイソトープ治療が大きな注目を集めている。その治療効果を細胞実験により検証する過程において、2次元的に拡がった培養細胞（以下2D）と，スフェロイドと呼ばれる3次元的な構造を持つ培養細胞を用いた実験（以下3D）において、標識するRIにより2Dと3Dの生存率の結果の関係が逆転することが分かった。\n　本研究では、この両者の違いを、PHITSを用いて線量分布を詳細に解析することにより、2Dと3D培養細胞の生存率の違いが、標識RIの放射線の違いと、薬剤の3次元的な空間分布の違いに起因することを明らかにした。\n　なお、本研究の推進にあたり、新規にPHITS2.88以降に追加されたメッシュ空間分布線源発生機能とβ崩壊核種に対するRI線源機能を活用した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第13回PHITS研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂下哲哉"}],"nameIdentifiers":[{"nameIdentifier":"655837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 達彦"}],"nameIdentifiers":[{"nameIdentifier":"655838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠原, 彩花"}],"nameIdentifiers":[{"nameIdentifier":"655839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"655840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"花岡, 宏史"}],"nameIdentifiers":[{"nameIdentifier":"655841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂下 哲哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655843","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"標的アイソトープ治療の治療効果推定を目指した3D培養細胞実験解析へのPHITSの適用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"標的アイソトープ治療の治療効果推定を目指した3D培養細胞実験解析へのPHITSの適用"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-26"},"publish_date":"2018-03-26","publish_status":"0","recid":"66695","relation_version_is_last":true,"title":["標的アイソトープ治療の治療効果推定を目指した3D培養細胞実験解析へのPHITSの適用"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:46:02.118364+00:00"}