{"created":"2023-05-15T14:48:40.891418+00:00","id":66691,"links":{},"metadata":{"_buckets":{"deposit":"d671cfd2-3b54-4ccb-9ea1-46e55dc944e3"},"_deposit":{"created_by":1,"id":"66691","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66691"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066691","sets":["10:29"]},"author_link":["655793","655800","655794","655797","655795","655792","655798","655799","655796","655791","655789","655790"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-11-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"標的アイソトープ治療に資する候補核種の一つにAt-211（α, 7.2 h）が挙げられる。ハロゲンに属するAt-211は，核医学で汎用されるヨウ素と同様の標識法が利用できると共に，アルファ線の効果によって高い細胞傷害性を期待出来る等，応用上の魅力が極めて高い。我々は小児神経芽腫等の治療効果が期待されるm-[211At]astato-benzylguanidine (MABG) を候補化合物に定め，管状ガラス反応器による遠隔製造を試みた。At-211は209Bi(α,2n)反応によって製造し，乾留法によって分離後，約0.5 mLのクロロホルムに回収した。MABGの原料にm-trimethylsilyl-BG（市販品），酸化剤にN-chloro-succinimideをそれぞれ選択し70℃10分の反応を行った。得られた粗製MABGはSep-Pak tC18にて精製を行い，全収率として約60%を示した（減衰補正なし）。本法により効率的なMABG標識が可能になった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第56回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永津, 弘太郎"}],"nameIdentifiers":[{"nameIdentifier":"655789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸, 克行"}],"nameIdentifiers":[{"nameIdentifier":"655790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"655791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"655792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 茂樹"}],"nameIdentifiers":[{"nameIdentifier":"655793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇, 厚生"}],"nameIdentifiers":[{"nameIdentifier":"655794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸 克行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島 康宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 茂樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇 厚生","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655800","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"211At-MABGの遠隔製造に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"211At-MABGの遠隔製造に関する検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-26"},"publish_date":"2018-03-26","publish_status":"0","recid":"66691","relation_version_is_last":true,"title":["211At-MABGの遠隔製造に関する検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:46:04.854866+00:00"}